University of Pennsylvania · Department of Bioengineering

Cellular & Molecular Imaging Lab

The rapid advancement in our understanding of the regulatory and signaling pathways responsible for cell growth, differentiation, and death has led to the identification of an array of anomalies in the genome and proteome that can be associated with disease. Our laboratory is interested in developing molecular imaging probes that target these anomalies to locate and study diseased states in vivo. We are developing probes that target a wide range of biological processes including gene regulation, mRNA localization, protein expression, and enzymatic activity. Multiple imaging platforms are used including magnetic resonance, fluorescence, and bioluminescence and applications range from studying the complex intracellular dynamics of individual cells to the early detection of disease in a clinical setting.