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Mechanobiology
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News

Profile of Scott Diamond in Penn Engineering, Spring 2013

"Diamond uses liquid-handling robots, originally developed for the pharmaceutical industry, to run thousands of measurements on a small volume of an individual's blood. "Each person's blood has a unique personality, a phenotype, in the way it responds to all the many different stimuli present during a clotting event," Diamond says. His team uses these data sets to train computer models to predict the severity of a heart attack given one's blood profile. These computer simulations help identify the patient-specific benefits or risks of a particular drug therapy."

Read the entire article online here, or download a PDF of the entire issue of Penn Engineering.

Science News: "New Aspect of Platelet Behavior in Heart Attacks Revealed: Clots Can Sense Blood Flow"

Science News reports on research (Nov 2012) conducted at the Diamond lab by Ryan Muthard and Scott Diamond, showing that clots forming under arterial-flow conditions have an unexpected ability to sense the surrounding blood moving over it.If the flow stops, the clot senses the decrease in flow and this triggers a contraction similar to that of a muscle. The contraction squeezes out water, making the clot denser. Better understanding of the clotting dynamics that occur in atherosclerosis, as opposed to the dynamics at play in closing a wound, could lead to more effective drugs for heart-attack prevention.

Science News: "Large-Scale Simulation of Human Blood Is Boon to Personalized Medicine"

Science News reports on research (May 2012) conducted at the Diamond Lab by Scott Diamond and Talid Sinno, with Matthew Flamm, Tom Colace and Manash Chatterjee. The team developed multi-scale models of blood flow to predict how platelets responded to blood vessel damage under the influence of a variety of anti-coagulation drugs. This enables the development of personalized "virtual blood" computer models that can predict the effectiveness of anticoagulation drugs for particular patients.

New Publication Featured on Cover: Flamm MH, Colace TV, Chatterjee MS, Jing H, Zhou S, Jaeger D, Brass LF, Sinno T, Diamond SL Multiscale prediction of patient-specific platelet function under flow. Blood 2012 120(1):190-198.

Special Editorial: Neelamegham S. The computing platelet: integrating environmental cues Blood 2012 120:3-4

Science News: "Bioengineers Create Simulator to Test Blood Platelets in Virtual Heart Attacks"

Science News reports that Researchers Manash Chatterjee and Scott Diamond of the Diamond Lab, working with Jeremy E. Purvis of the Department of Genomics and Computational Biology and Lawrence F. Brass of the Department of Medicine at Penn, have trained a computer neural network model to accurately predict how blood platelets would respond to complex conditions found during a heart attack or stroke. The research team developed its experimental/computational technique, called Pairwise Agonist Scanning, or PAS, to define platelet response to combinations of agonists, chemicals that bind in this case to platelet cells, initiating a cellular response. The online article is here.

Systems Biology Symposium

The Diamond Lab hosted a Systems Biology Symposium on June 23-24, 2009, in the Wu and Chen Auditorium at Levine Hall and the Computing Labs of the Moore Building. You can read the Program Booklet, and see photos of the event, on our page for the Symposium.

 

New Publication Featured on Cover: Maloney SF, Brass LF, Diamond SL P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integr Biol (Camb) 2010 2(4):183-192.

New Publication Featured on Cover: Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL. Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J Thromb Haemost Sep 15 2012;  

NEW PUBLICATION: A series of cationic sterol lipids with gene transfer and bactericidal activity, published in Bioorganic & Medicinal Chemistry

[Abstract] [PDF]

NEW PUBLICATION: Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor, published in the Journal of Medicinal Chemistry

[Abstract] [PDF]

NEW PUBLICATION: Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis, published in Arteriosclerosis, Thrombosis, and Vascular Biology

[Abstract] [PDF]

 

 

NEW PUBLICATION : Steady-State Kinetic Modeling Constrains Cellular Resting States and Dynamic Behavior, published in PLOS Computational Biology.

[Abstract] [PDF]

NEW PUBLICATION: Lattice kinetic Monte Carlo simulations of convective-diffusive systems, published in the Journal of Chemical Physics.

[Abstract] [PDF]

Scott Diamond awarded Heilmeier Excellence in Research Award
Award Seminar "High Throughput Biotechnology" (March 4, 2009, 4:30 p.m., Wu and Chen Auditorium)

Scott Diamond Named BMES Fellow

NEW PUBLICATION : Computational Model of Platelet Activation, published in Blood.

[Full Text] [PDF]

Special Editorial: Michael C. Berndt and Robert K. Andrews, " Systems biology meets platelet biology." Blood 2008 112:3920-3921

[Full Text] [PDF]

 

NEW PUBLICATION: Microfluidic Device for Murine Thrombosis Studies, published in the Journal of Thrombosis and Haemostasis.

[Abstract] [PDF]

New Publication featured on the cover of Molecular Pharmacology

Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L
Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing, Heather J. Grieser, Elizabeth R. Sharlow, Andrew D. Napper, Donna M. Huryn, Barry S. Cooperman, Amos B. Smith, III, and Scott L. Diamond
Mol Pharmacol 2008 74: 34-41. Published online April 10, 2008
[Abstract] [Full Text] [PDF]

 

Nov. 20th, 2007: High Throughput Chemical Biology Symposium

Biotechnology Short Course on July 24-25, 2007

$2.8 Million for Systems Biology

The University of Pennsylvania was awarded a $2.8 million grant as one of three national centers for Systems Biology by the National Heart, Lung, and Blood Institute of the NIH.

The three-year project will focus on “Blood Systems Biology” and is headed by Dr. Scott L. Diamond, Arthur E. Humphrey Professor of Chemical and Biomolecular Engineering and Bioengineering; Associate Director and Charter Member, Institute for Medicine and Engineering; Director, Biotechnology Program; and Director, Penn Center for Molecular Discovery.

The Cluster Team will deploy integrative and hierarchical computational models and experimental studies to predict spatial-temporal processes in mouse and human blood under hemodynamic conditions. An interdisciplinary team of faculty from the School of Engineering and Applied Sciences includes Drs. Daniel Hammer (bioengineering), Talid Sinno (chemical and biomolecular engineering) and George Biros (mechanical engineering and applied mechanics) along with Dr. Skip Brass (medicine and pharmacology) and Dr. Mark Kahn (cardiovascular medicine) from the School of Medicine. The team has expertise in experimental and computational hemodynamics, platelet biology, coagulation and protease biochemistry, continuum/stochastic simulation, robotic automation, and knockout mice for thrombosis research.

“Blood is ideal for Systems Biology research since it is easily obtained from donors or patients, amenable to high throughput liquid handling experiments, and clinically relevant,” said Dr. Diamond. “Better elucidation and quantitative simulation of blood reactions and platelet signaling pathways under hemodynamic conditions are directed at clinical needs in thrombosis risk assessment, anti-coagulation therapy, platelet targeted therapies, and stroke research,” he added.

$9.5 Million from NIH for Penn Center for Molecular Discovery

The University of Pennsylvania is receiving $9.5 million from the National Institutes of Health during the next three years to establish the Penn Center for Molecular Discovery. The Penn team will screen the NIH repository of compounds to discover new biological interactions. [read full story...]

 

 

 

 

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