News

Systems Biology Symposium

The Diamond Lab hosted a Systems Biology Symposium on June 23-24, 2009, in the Wu and Chen Auditorium at Levine Hall and the Computing Labs of the Moore Building. You can read the Program Booklet, and see photos of the event, on our page for the Symposium.

	NEW PUBLICATION: A series of cationic sterol lipids with gene transfer and bactericidal activity, published in Bioorganic & Medicinal Chemistry [Abstract] [PDF]
	NEW PUBLICATION: Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor, published in the Journal of Medicinal Chemistry [Abstract] [PDF]
	NEW PUBLICATION: Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis, published in Arteriosclerosis, Thrombosis, and Vascular Biology [Abstract] [PDF]
	NEW PUBLICATION : Steady-State Kinetic Modeling Constrains Cellular Resting States and Dynamic Behavior, published in PLOS Computational Biology. [Abstract] [PDF]
	NEW PUBLICATION: Lattice kinetic Monte Carlo simulations of convective-diffusive systems, published in the Journal of Chemical Physics. [Abstract] [PDF]

Scott Diamond awarded Heilmeier Excellence in Research Award
Award Seminar "High Throughput Biotechnology" (March 4, 2009, 4:30 p.m., Wu and Chen Auditorium)

Scott Diamond Named BMES Fellow

	NEW PUBLICATION : Computational Model of Platelet Activation, published in Blood. [Abstract] [PDF]
	NEW PUBLICATION: Microfluidic Device for Murine Thrombosis Studies, published in the Journal of Thrombosis and Haemostasis. [Abstract] [PDF]

New Publication featured on the cover of Molecular Pharmacology

Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L
Parag P. Shah, Michael C. Myers, Mary Pat Beavers, Jeremy E. Purvis, Huiyan Jing, Heather J. Grieser, Elizabeth R. Sharlow, Andrew D. Napper, Donna M. Huryn, Barry S. Cooperman, Amos B. Smith, III, and Scott L. Diamond
Mol Pharmacol 2008 74: 34-41. Published online April 10, 2008
[Abstract] [Full Text] [PDF]

Nov. 20th, 2007: High Throughput Chemical Biology Symposium

Biotechnology Short Course on July 24-25, 2007

$2.8 Million for Systems Biology

The University of Pennsylvania was awarded a $2.8 million grant as one of three national centers for Systems Biology by the National Heart, Lung, and Blood Institute of the NIH.

The three-year project will focus on “Blood Systems Biology” and is headed by Dr. Scott L. Diamond, Arthur E. Humphrey Professor of Chemical and Biomolecular Engineering and Bioengineering; Associate Director and Charter Member, Institute for Medicine and Engineering; Director, Biotechnology Program; and Director, Penn Center for Molecular Discovery.

The Cluster Team will deploy integrative and hierarchical computational models and experimental studies to predict spatial-temporal processes in mouse and human blood under hemodynamic conditions. An interdisciplinary team of faculty from the School of Engineering and Applied Sciences includes Drs. Daniel Hammer (bioengineering), Talid Sinno (chemical and biomolecular engineering) and George Biros (mechanical engineering and applied mechanics) along with Dr. Skip Brass (medicine and pharmacology) and Dr. Mark Kahn (cardiovascular medicine) from the School of Medicine. The team has expertise in experimental and computational hemodynamics, platelet biology, coagulation and protease biochemistry, continuum/stochastic simulation, robotic automation, and knockout mice for thrombosis research.

“Blood is ideal for Systems Biology research since it is easily obtained from donors or patients, amenable to high throughput liquid handling experiments, and clinically relevant,” said Dr. Diamond. “Better elucidation and quantitative simulation of blood reactions and platelet signaling pathways under hemodynamic conditions are directed at clinical needs in thrombosis risk assessment, anti-coagulation therapy, platelet targeted therapies, and stroke research,” he added.

$9.5 Million from NIH for Penn Center for Molecular Discovery

The University of Pennsylvania is receiving $9.5 million from the National Institutes of Health during the next three years to establish the Penn Center for Molecular Discovery. The Penn team will screen the NIH repository of compounds to discover new biological interactions. [read full story...]