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Mechanobiology
Thrombolysis
Coagulation
Bioadhesion
Gene Therapy
Drug/Device
Proteomics
Drug Discovery
Systems Biology
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Drug/Device

Drug coated stents have demonstrated the large potential for combined design of device/drug delivery systems. In collaboration with neurosurgeons, we have investigated the use of platinum and degradable coils that are drug or gene coated for the purposes of nonsurgical treatment of cerebral aneurysms. We have developed a new rat model for coil testings that recreates arterial pressurization and stasis, the setting for aneurysm growth.

We have shown in an in vivo model of arterial stasis and pressurization that rhVEGF added to the platinum surface provides an enhanced cellular response compared with unmodified coils and coils modified with collagen. Our results suggest that factors with enhanced biological activity that are added to platinum coils may induce a better fibrotic reaction and improve occlusion rates of aneurysms, especially those that are large and/or with wide necks. The next step would be to use rhVEGFmodified coils in experimental jugular vein aneurysms to compare their efficacy to other GDC surface modifications.

 Publications

1. 2000

Abrahams JM, Diamond SL, Hurst RW, Zager EL, Grady MS. Topic review: surface modifications enhancing biological activity of guglielmi detachable coils in treating intracranial aneurysms. Surg Neurol 2000; 54 (1): 34-40; discussion 40-31

2. 2001

Abrahams JM, Forman MS, Grady MS, Diamond SL. Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model. AJNR Am J Neuroradiol 2001; 22 (7): 1410-1417

3.

Abrahams JM, Forman MS, Grady MS, Diamond SL. Biodegradable polyglycolide endovascular coils promote wall thickening and drug delivery in a rat aneurysm model. Neurosurgery 2001; 49 (5): 1187-1193; discussion 1193-1185

4. 2002

Abrahams JM, Song C, DeFelice S, Grady MS, Diamond SL, Levy RJ. Endovascular microcoil gene delivery using immobilized anti-adenovirus antibody for vector tethering. Stroke 2002; 33 (5): 1376-1382

5. 2004

Abrahams JM, Diamond SL. Endovascular Biologic Aneurysm Management. Management of Cerebral Aneurysms 2004; : 997-1006

 

 

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    Institute for Medicine & Engineering (IME)
    3340 Smith Walk
    1020 Vagelos Research Laboratories
    University of Pennsylvania
    Philadelphia, PA 19104-6383
    Lab No.: (215) 573-5704
    Fax: (215) 573-7227