coated stents have demonstrated the large potential for combined
design of device/drug delivery systems. In collaboration with neurosurgeons,
we have investigated the use of platinum and degradable coils that
are drug or gene coated for the purposes of nonsurgical treatment
of cerebral aneurysms. We have developed a new rat model for coil
testings that recreates arterial pressurization and stasis, the
setting for aneurysm growth.
We have shown in an in vivo model of arterial stasis and pressurization that rhVEGF added to the platinum surface provides an enhanced cellular response compared with unmodified coils and coils modified with collagen. Our results suggest that factors with enhanced biological activity that are added to platinum coils may induce a better fibrotic reaction and improve occlusion rates of aneurysms, especially those that are large and/or with wide necks. The next step would be to use rhVEGFmodified coils in experimental jugular vein aneurysms to compare their efficacy to other GDC surface modifications.
Abrahams JM, Diamond SL, Hurst RW, Zager EL, Grady MS. Topic review: surface modifications enhancing biological activity of guglielmi detachable coils in treating intracranial aneurysms. Surg Neurol 2000; 54 (1): 34-40; discussion 40-31
Abrahams JM, Forman MS, Grady MS, Diamond SL. Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model. AJNR Am J Neuroradiol 2001; 22 (7): 1410-1417
Abrahams JM, Forman MS, Grady MS, Diamond SL. Biodegradable polyglycolide endovascular coils promote wall thickening and drug delivery in a rat aneurysm model. Neurosurgery 2001; 49 (5): 1187-1193; discussion 1193-1185
Abrahams JM, Song C, DeFelice S, Grady MS, Diamond SL, Levy RJ. Endovascular microcoil gene delivery using immobilized anti-adenovirus antibody for vector tethering. Stroke 2002; 33 (5): 1376-1382
Abrahams JM, Diamond SL. Endovascular Biologic Aneurysm Management. Management of Cerebral Aneurysms 2004; : 997-1006