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Publications

  1. S. L. Diamond, S. G. Eskin, and L. V. McIntire, "Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells," Science 243, 1483 (1989).
  2. J. B. Sharefkin, S. L Diamond, C. W. Dieffenbach, and S. G. Eskin. "Effects of Sustained Laminar Shear Stress on Tissue Plasminogen Activator Levels," In: Cardiovascular Science and Technology (J. Norman, editor) Oxymoron Press, Louisville, p. 81 (1989).
  3. S. L. Diamond, J. B. Sharefkin, S. G. Eskin, C. Dieffenbach, K. Frasier-Scott, and L. V. McIntire, "Tissue Plasminogen Activator Messenger RNA Levels Increase in Cultured Human Endothelial Cells Exposed to Laminar Shear Stress," J. Cell. Physiol. 143, 364 (1990).
  4. J. B. Sharefkin, S. L. Diamond, S. G. Eskin, C. Dieffenbach, and L. V. McIntire, "Fluid Flow Decreases Endothelin mRNA Levels and Suppresses Endothelin Peptide Release in Human Endothelial Cells," J. Vasc. Surg. 14, 1 (1991).
  5. S. L.Diamond, J. B.Sharefkin, C. W. Dieffenbach, S. G.Eskin, and L. V. McIntire, "Regulation of Endothelial Cell Gene Expression by Hemodynamic Forces: Implications for Intimal Hyperplasia and Graft Patency," In: Technologies in Vascular Surgery, W. B. Saunders, Philadelphia (J. S. T. Yao and W. H. Pearce, eds.) p. 12-24 (1991).
  6. M. U. Nollert, S. L. Diamond, and L. V. McIntire, "Hydrodynamic Shear Stress and Mass Transport Modulation of Endothelial Cell Metabolism," Biotech. Bioengr. 38, 588 (1991).
  7. W. Sigurdson, F. Sachs, and S. L. Diamond, "Mechanical Perturbation of Cultured Human Endothelial Cells Causes Rapid Increases of Intracellular Calcium." Amer. J. Physiology 264, H1745 (1993).
  8. M.Yamaguchi, S. L. Diamond, H. Watanabe, H. Gallati, W. Baur, and J. B. Sharefkin. Heparin and Dibutyryl cAMP Modulate Gene Expression in Stimulated Human Saphenous Vein Smooth Muscle Cells. In Vitro Cell. Devel. Biol. 29, 863 (1993).
  9. S. L. Diamond and S. Anand, "Inner Clot Diffusion and Permeation During Fibrinolysis," Biophysical J. 65, 2622 (1993).
  10. V. Ranjan and S. L. Diamond, "Fluid Shear Stress Induces Synthesis and Nuclear Localization of c-Fos in Cultured Human Endothelial Cells," Biochem. Biophys. Res. Comm. 196, 79 (1993).
  11. J. H. Wu, K. A. Siddiqui, and S. L. Diamond. "Transport Phenomena and Clot Dissolving Therapy: An Experimental Investigation of Diffusion-Controlled and Permeation-Enhanced Fibrinolysis." Thrombosis Haemostasis 72, 105 (1994).
  12. S. L. Diamond, F. Sachs, and W. J. Sigurdson. "The Mechanically-Induced Calcium Mobilization in Cultured Endothelial Cells is Dependent on Actin and Phospholipase," Arteriosclerosis Thrombosis 14, 2000 (1994).
  13. S. L. Diamond and A. I. Kozak, "A Course in Biotechnology and Society," Chemical Engineering Education 28, 140 (1994).
  14. J. H. Wu and S. L. Diamond, "A Fluorescence Quench and Dequench Assay for Fibrinogen Polymerization, Fibrinogenolysis, or Fibrinolysis," Analytical Biochem. 224, 83 (1995).
  15. S. L. Diamond and L. V. McIntire, "Gene Regulation in Endothelial Cells," In: Flow Dependent Regulation of Vascular Function in Health and Disease," Oxford University Press, New York (J. A. Beven, G. Kaley, G. M. Rubanyi, eds.) Chapter 4. p. 62-84 (1995).
  16. J. H. Wu and S. L. Diamond. "Tissue Plasminogen Activator Inhibits Plasmin Degradation of Fibrin: A Mechanism that Slows tPA-mediated Fibrinolysis but Does Not Require 2-antiplasmin or Leakage of Intrinsic Plasminogen," J. Clinical Investigation 95, 2483 (1995).
  17. V. Ranjan, S. Z. Xiao, and S. L. Diamond. "Constitutive NOS Expression in Cultured Endothelial Cells is Elevated by Fluid Shear Stress." Amer. J. Physiol. 268, H550 (1995).
  18. J. H. Wu and S. L. Diamond. "Fluorogenic Fibrinogen and Fibrin Facilitate Macromolecular Assembly and Dynamic Measurement of Picomolar Levels of Plasminogen Activators under Well Mixed Conditions." Thrombosis Haemostasis 74, 711 (1995).
  19. S. Anand, J. H. Wu, and S. L. Diamond. "Enzyme Mediated Proteolysis of Fibrous Biopolymers: Dissolution Front Movement in Fibrin or Collagen under Conditions of Diffusive or Convective Transport." Biotech. Bioeng. 48, 89 (1995).
  20. V. Ranjan, R. Waterbury, and S. L. Diamond. "Fluid Shear Stress Induction of the Transcriptional Activator c-fos in Human and Bovine Endothelial Cells, HeLa, and CHO Cells." Biotech. Bioeng. 49, 383 (1996).
  21. S. Anand and S. L. Diamond. "Computer Simulation of Systemic Circulation and Clot Lysis Dynamics During Thrombolytic Therapy That Accounts for Inner Clot Transport and Reaction." Circulation. 94, 763 (1996).
  22. D.S. Vaidya, J.M. Nitsche, S.L. Diamond, D.A. Kofke. "Convection-Diffusion of Solutes in Dynamic Media" Adsorption 3, 41 (1996).
  23. D.S. Vaidya, J.M. Nitsche, S.L. Diamond, D.A. Kofke. "Convection-Diffusion of Solutes in Media with Piecewise Constant Transport Properties." Chem. Eng. Sci. 51, 5299 (1996).
  24. A. Subramanian, S.L. Diamond. "Enhancement of nonviral gene transfer to endothelial cells using lipofection of histone complexed DNA," Tissue Engineering 3, 39 (1997).
  25. D.S. Vaidya, J.M. Nitsche, S.L. Diamond, D.A. Kofke. "Perturbation Solution to the Convection-Diffusion Equation with Moving Fronts." AICHE J. 43, 631 (1997).
  26. Z. Xiao, X. Zhang, S.L. Diamond. "Shear stress induction of endothelial nitric oxide synthase is calcium-dependent, but not calcium-activated." J. Cell. Physiol. 171, 205 (1997).
  27. W. Wang, S.L. Diamond. Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells? Biochem. Biophys. Res. Comm. 233, 748 (1997).
  28. D.S. Vaidya, S.L. Diamond, J.M. Nitsche D.A. Kofke. "Potential for use of liquid crystals as dynamically tunable electrophoretic media." AICHE J. 43, 1366 (1997).
  29. S. Anand, V. Kudallur, B. Pitman, S. L. Diamond. "Mechanisms by which thrombolytic therapy results in nonuniform lysis and residual thrombus after reperfusion." Ann. Biomed. Engr. 25, 964 (1997).
  30. S. L. Diamond. "Engineering Approaches for Thrombolytic Therapy" BMES Bulletin. 21, 3 (1997).
  31. P. Tandon, S. L. Diamond. "Hydrodynamic effects and receptor interactions of platelets and their aggregates in linear shear flow." Biophysical J. 73, 2819 (1997).
  32. P. Tandon, S. L. Diamond. "Kinetics of b2-integrin and L-selectin bonding during neutrophil aggregation in shear flow." Biophysical J. 75, 3163 (1998).
  33. W. J. Calvo, G. Hajduczok, J.A. Russell, and S.L. Diamond. "Inhibition of nitric oxide but not prostacyclin prevents poststenotic dilatation in rabbit femoral artery." Circulation. 99, 1069 (1999).
  34. S. L. Diamond. "Engineering Design of Optimal Strategies for Blood Clot Dissolution" Annual Reviews of Biomedical Engineering. 1, 27 (1999).
  35. Z. Zhang, Z. Ziao, and S. L. Diamond. "Shear stress induction of C-type natriuretic peptide (CNP) in endothelial cells is independent of NO autocrine signaling" Annals Biomed. Engr. 27, 419 (1999).
  36. I. Laurenzi, S. L. Diamond. "Monte Carlo solution of heterotypic aggregation kinetics of platelets and neutrophils." Biophysical J. 77, 1733 (1999).
  37. A. Subramanian, P. Ranganathan, S. L. Diamond. "Nuclear targeting peptide scaffold for lipofection of nondividing mammalian cells." Nature Biotechnology. 17, 873 (1999).
  38. S. L. Diamond, P. Tandon, D. Schmidtke, I. Laurenzi. "Cellular Aggregation in Blood Flow." Comments Theoretical Biol. 8, 1 (2000).
  39. S. L. Diamond. "Intracellular Receptors--Steroid Receptors and Nitric Oxide." Animal Plant Cell Tech. 7, 1097 (2000).
  40. D. Schmidtke, S. L. Diamond. "Direct observation of membrane tethers formed during neutrophil attachment to adherent platelets or P-selectin in physiological shear flow." J. Cell. Biol. 179, 719 (2000).
  41. J. M. Abrahams, S. L. Diamond, R. W. Hurst, E.L. Zager, M.S. Grady. Surface modifications Enhancing Biological Activity of Guglielmi Detachable Coils in Treating Intracranial Aneurysms. Surgical Neurology 54, 34 (2000).
  42. H. Ma, S.L. Diamond. Non-viral gene therapy and its delivery systems. Curr. Pharmaceut. Biot. 2, 1 (2001).
  43. S.L. Diamond. Reaction complexity in flowing human blood. Biophysical J. 80, 1031(2001).
  44. J. M. Abrahams, M.S. Forman, M. S. Grady, S. L. Diamond. Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model. Amer. J. Neuroradiology. 22,1410 (2001).
  45. J.M. Abrahams, M. S. Forman, M. S. Grady, and S. L. Diamond. Biodegradable polyglycolide endovascular coils promote wall thickening and drug delivery in a rat aneurysm model. Neurosurgery. 49, 1187 (2001).
  46. M. Goel, S.L. Diamond. Neutrophil enhancement of fibrin deposition under flow though platelet-independent and platelet-dependent mechanisms. Arteriol. Thromb. Vasc. Biol. 21, 2093 (2001).
  47. C.K. Byrnes, P. H. Nass, M. D. Duncan, S.L. Diamond, J. W. Harmon. Assessment of a nuclear targeting peptide scaffold (M9) to improve plasmid DNA transfection efficiency. Surg. Forum. 102, 538 (2001).
  48. A. Subramanian, H. Ma, K.N. Dahl, J. Zhu, and S.L. Diamond. Adenovirus or HA-2 peptide assisted lipofection increases cytoplasmic plasmid in nondividing endothelium with little enhancement of transgene expression. J. Gene Med. 4:75 (2002).
  49. I.J. Laurenzi, S.L. Diamond. Multicomponent Aggregation and Gel Formation via Simultaneous Convection and Diffusion. I.E.C.&R. 40: 413 (2002).
  50. E.Y.H. Park, M.J. Smith, E. S. Stropp, J. A. Diveietro, W. F. Walker, D.W. Schmidtke, S.L.Diamond, M.B. Lawrence. Comparison of PSGL-1 microbead and neutrophil rolling: Microvillus elongation stabilizes P-selectin clusters. Biophysical J. 82, 1835 (2002).
  51. JM. Abrahams, C Song, MS Grady, SL Diamond, RJ Levy. Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering. Stroke. 33, 1376 (2002).
  52. I.J. Laurenzi, J.D. Bartels, S.L. Diamond. A general algorithm for exact numerical simulation of multi-component aggregation. J. Comput. Phys. 177, 418 (2002).
  53. M. Frojmovic, G. Nash, S.L. Diamond. Cell Aggregation and Cell Adhesion in Flow. Thromb. Haem. 87, 771 (2002).
  54. H. Ma, J. Zhu, M. Maronski, V.M.Y. Lee, M. Dichter, S.L. Diamond. Nonclassical nuclear localization signal peptides for high efficiency lipofection of primary neurons and neuronal cell lines. Neuroscience 111, 1 (2002).
  55. T. A. Doggett, G. Girdhar, A. Lawshe, D. W. Schmidtke, I. J. Laurenzi, S. L. Diamond, T. G. Diacovo. Selectin-like Kinetics and Biomechanics Promote Rapid Platelet Adhesion in Flow: The GPIb?-vWF Tether Bond. Biophysical J. 83, 194 (2002).
  56. M. Goel, S. L. Diamond. Adhesion of normal erythrocytes to activated neutrophils, activated platelets, and fibrin polymerized from plasma at depressed venous shear rates. Blood. 100, 3739 (2002).
  57. E. A. Pierce, Q. Liu, O. Igoucheva, H.Ma, R. Omarrudin, S. L. Diamond, K. Yoon. Oligonucleotide-directed single base DNA alterations in mouse embryonic stem cells. Gene Therapy. 10:24 (2003).
  58. M.Goel, S.L. Diamond. Neutrophil cathepsin G enhances prothrombinase and fibrin formation under flow by activating fibrinogen-adherent platelets. J. Biol. Chem. 278, 9458 (2003).
  59. J. Y. Ji, H. Jing, S. L. Diamond. Shear stress enhances nuclear localization of endothelial glucocorticoid receptor and expression from the GRE promoter. Circ. Res. 92, 279 (2003).
  60. I.J. Laurenzi, S.L. Diamond. Kinetics of Reversible Aggregation and Gelation with Multiple Components. Phys. Rev. E. 67, 51103 (2003).
  61. T.A. Doggett, G. Girdhar, A. Lawshe, J.L. Miller, I.J. Laurenzi, S.L. Diamond, T.G. Diacovo. Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val.. Blood 102, 152 (2003).
  62. D. Gosalia, S.L. Diamond. Printing chemical libraries for nanoliter fluid phase reactions. Proc. Natl. Acad. Sci. USA (Track II) 100, 8721 (2003).
  63. D. M. Eckmann, S.L. Diamond. Surfactants attenuate gas embolism-induced thrombin production. Anesthesiology 100, 77 (2004).
  64. H. Ma, Q. Liu, S.L. Diamond, and E.A. Pierce. Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency. Methods. 33:113 (2004).
  65. J. Gruneich, A. R. Price, H. Jing, S. L. Diamond. Cationic corticosteroid for nonviral gene delivery. Gene Therapy 11:668 (2004).
  66. M. Goel, S. L. Diamond. Thrombosis. Encyclopedia of Biomaterials and Biomedical Engineering. Eds. G. E. Wnek, G. L. Bowlin. Marcel Dekker. (2004).
  67. J. M. Abrahams, S. L. Diamond. Biological and Future Management of Aneuryms. In "Management of Cerebral Aneurysms." Eds. P.D. LeRoux and H.R. Winn. Elsevier Science. (2004).
  68. K.A. Kadash, M.B. Lawrence, S.L. Diamond. Neutrophil String Formation: Hydrodynamic thresholding and cell deformation during cell collisions. Biophysical J. 86:(2004).
  69. M. Goel, S. L. Diamond. Factor VIIa-mediated tenase function on activated platelets under flow. J. Thromb. Haem. 2:1402 (2004).
  70. J. Ji, S. L. Diamond. Exogenous nitric oxide activates the endothelial glucocorticoid receptor. Biochem. Biophys. Res. Comm. 318:192 (2004).
  71. K. Lo and S. L. Diamond. Blood coagulation kinetics: High throughput method for realtime reaction monitoring. Thromb. Haem. 92:874 (2004).
  72. H. Ma, K. Y. Horiuchi, Y. Wang, S. A. Kucharewicz, S. L. Diamond. Nanoliter Homogeneous Ultra High Throughput Screening Microarray for Lead Discoveries and IC50 Profiling. Assay & Drug Develop.Tech.. 3:177 (2005).
  73. A. Price, M. Limberis, J. Gruneich, J. M. Wilson, S. L. Diamond. Targeting viral-mediated transduction to the lung airway epithelium with the anti-inflammatory cationic lipid dexamethasone-spermine. Molecular Therapy. 12:502 (2005).
  74. Edmondson KE, Denney WS, Diamond SL: Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime. Biophys J 2005, 89:3603-3614.
  75. Gosalia DN, Salisbury CM, Ellman JA, Diamond SL: High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays. Mol Cell Proteomics 2005, 4:626-636.
  76. Gosalia DN, Salisbury CM, Maly DJ, Ellman JA, Diamond SL: Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays. Proteomics 2005, 5:1292-1298.
  77. Lo K, Denney WS, Diamond SL: Stochastic modeling of blood coagulation initiation. Pathophysiol Haemost Thromb 2005, 34:80-90.
  78. Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P: Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A 2005, 102:11876-11881.
  79. Ganguly K, Goel MS, Krasik T, Bdeir K, Diamond SL, Cines DB, Muzykantov VR, Murciano JC: Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo. J Pharmacol Exp Ther 2006, 316:1130-1136.
  80. Gosalia DN, Denney WS, Salisbury CM, Ellman JA, Diamond SL: Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray. Biotechnol Bioeng 2006, 94:1099-1110.
  81. Horiuchi KY, Wang Y, Diamond SL, Ma H: Microarrays for the functional analysis of the chemical-kinase interactome. J Biomol Screen 2006, 11:48-56.
  82. Kim MS, Diamond SL: Controlled release of DNA/polyamine complex by photoirradiation of a solid phase presenting o-nitrobenzyl ether tethered spermine or polyethyleneimine. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5572-5.
  83. Kim MS, Diamond SL: Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications. Bioorg Med Chem Lett 2006, 16:4007-4010.
  84. Murphy BR, Moayedpardazi HS, Gewirtz AM, Diamond SL, Pierce EA: Delivery and mechanistic considerations for the production of knock-in mice by single-stranded oligonucleotide gene targeting. Gene Ther. 2007 Feb;14(4):304-15.
  85. Okorie UM, Diamond SL: Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow. Biophys J. 2006 Nov 1;91(9):3474-81.
  86. Diamond SL:. Methods for mapping protease specificity. Curr Opin Chem Biol. 2007 Feb;11(1):46-51.
  87. Gruneich JA, Diamond SL: Synthesis and structure-activity relationship of a series of increasingly hydrophobic cationic steroid lipofection reagents. J. Gene Medicine 9 2007 May;9(5):381-91
  88. Handwerger RG and Diamond SL: Photolytic biotinylated PEI: Capture and triggered release of nucleic acids from solid supports. J. Bioconj. Chem. 2007 May-June;18(3):717-723
  89. Price AR, Limberis MP, Wilson JM, Diamond SL. Pulmonary delivery of adenovirus vector formulated with dexamethasone-spermine facilitates homologous vector re-administration. Gene Ther. 2007 No;14(22):1594-604
  90. Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB 3rd. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4761-6. Epub 2007 Jul 5.
  91. Okorie UM, Denney WS, Chatterjee MS, Neeves KB, Diamond SL. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood. 2008 Jan 22;
  92. Myers MC, Shah PP, Diamond SL, Huryn DM, Smith AB 3rd. Identification and synthesis of a unique thiocarbazate cathepsin L inhibito.
    Bioorg Med Chem Lett. 2008 Jan 1;18(1):210-4. Epub 2007 Nov 1.
  93. de Almeida RA, Burgess D, Shema R, Motlekar N, Napper AD, Diamond SL, Pavitt GD. A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening. Yeast. 2008 Jan;25(1):71-6
  94. Ahn, Hyun Hee; Lee, Min Suk; Cho, Mi Hee; Shin, Yu Na; Lee, Jung Hwa; Kim, Kyung Sook; Kim, Moon Suk; Khang, Gilson; Hwang, Ki Chul; Lee, Il Woo; Diamond, Scott L.; Lee, Hai Bang. DNA/PEI nano-particles for gene delivery of rat bone marrow stem cells. Colloids and Surfaces A-Physiochemical and Engineering Aspects 313: 116-120 Sp. Iss. SI FEB 1 2008
  95. Ji JY, Jing H, Diamond SL. Hemodynamic regulation of inflammation at the endothelial-neutrophil interface. Ann Biomed Eng. 2008 Apr;36(4):586-95. Epub 2008 Feb 26.
  96. Diamond SL, Lawrence MB, Neelamegham S. Harry L. Goldsmith, Ph.d. Ann Biomed Eng. 2008 Apr;36(4):523-6.
  97. Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB 3rd, Diamond SL. Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol. 2008 Jul;74(1):34-41.
  98. Neeves KB, Diamond SL. A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood. Lab Chip. 2008 May;8(5):701-9.
  99. Myers MC, Shah PP, Beavers MP, Napper AD, Diamond SL, Smith AB 3rd, Huryn DM. Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3646-51.
  100. Diamond SL, Greenbaum D. Proteases' prime targets revealed. Nat Biotechnol. 2008 Jun;26(6):652-3.
  101. Motlekar N, Diamond SL, Napper AD. Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev Technol. 2008 Jun;6(3):395-405.
  102. Purvis JE, Chatterjee MS, Brass LF, Diamond SL. A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation. Blood. 2008 Jul 2.
  103. Beavers MP, Myers MC, Shah PP, Purvis JE, Diamond SL, Cooperman BS, Huryn DM, Smith AB 3rd. Molecular docking of cathepsin L inhibitors in the binding site of papain. J Chem Inf Model. 2008 Jul;48(7):1464-72.
  104. Oh H, Siano B and Diamond SL. Neutrophil Isolation Protocol. Journal of Visualized Experiments, Issue 17, July 23, 2008.
  105. Oh H and Diamond SL. Ethanol Enhances Neutrophil Membrane Tether Growth and Slows Rolling on P-Selectin but Reduces Capture from Flow and Firm Arrest on IL-1-Treated Endothelium. J Immunol. 2008 Aug 15;181(4):2472-82.
  106. Wong EY, Diamond SL. Enzyme microarrays assembled by acoustic dispensing technology. Anal Biochem. 2008 Oct 1;381(1):101-6.
  107. Barker GA, Diamond SL. RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection. Mol Ther. 2008 Sep;16(9):1602-8.
  108. Huang AH, Motlekar NA, Stein A, Diamond SL, Shore EM, Mauck RL.High-throughput screening for modulators of mesenchymal stem cell chondrogenesis. Ann Biomed Eng. 2008 Nov;36(11):1909-21. Epub 2008 Sep 13.
  109. Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost. 2008 Oct 7.
  110. Wong EY, Diamond SL.Advancing Microarray Assembly with Acoustic Dispensing Technology. Anal Chem. 2008 Nov 26.
  111. Purvis, J. E., R. Radhakrishnan and S. L. Diamond (2009). Steady-State Kinetic Modeling Constrains Cellular Resting States and Dynamic Behavior. PLoS Computational Biology 5(3): e1000298. doi:10.1371/journal.pcbi.1000298.
  112. Flamm, M. H., S. L. Diamond and T. Sinno (2009). Lattice kinetic Monte Carlo simulations of convective-diffusive systems. The Journal of Chemical Physics 130(9): 094904-7.
  113. Anand R, Maksimoska J, Pagano N, Wong EY, Gimotty PA, Diamond SL, Meggers E, Marmorstein R. Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. J Med Chem. 2009 Mar 26;52(6):1602-11.
  114. Randazzo RA, Bucki R, Janmey PA, Diamond SL. A series of cationic sterol lipids with gene transfer and bactericidal activity. Bioorg Med Chem. 2009 May 1;17(9):3257-65. Epub 2009 Apr 1.
  115. Zhu L, Stalker TJ, Fong KP, Jiang H, Tran A, Crichton I, Lee EK, Neeves KB, Maloney SF, Kikutani H, Kumanogoh A, Pure E, Diamond SL, Brass LF. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1039-45. Epub 2009 Apr 23.
  116. Diamond SL. Systems biology to predict blood function. J Thromb Haemost. 2009 Jul;7 Suppl 1:177-80. Review.
  117. Fein DE, Limberis MP, Maloney SF, Heath JM, Wilson JM, Diamond SL. Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung. Mol Ther. 2009 Dec;17(12):2078-87. Epub 2009 Jul 28.
  118. Oh H, Mohler ER 3rd, Tian A, Baumgart T, Diamond SL. Membrane cholesterol is a biomechanical regulator of neutrophil adhesion. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1290-7. Epub 2009 Aug 10.
  119. Motlekar N, de Almeida RA, Pavitt GD, Diamond SL, Napper AD. Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast. Assay Drug Dev Technol. 2009 Oct;7(5):479-94.
  120. Stalker TJ, Wu J, Morgans A, Traxler EA, Wang L, Chatterjee MS, Lee D, Quertermous T, Hall RA, Hammer DA, Diamond SL, Brass LF. Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo. J Thromb Haemost. 2009 Nov;7(11):1886-96. Epub 2009 Sep 9.
  121. Pagano N, Wong EY, Breiding T, Liu H, Wilbuer A, Bregman H, Shen Q, Diamond SL, and Meggers E. From Imide to Lactam Metallo-Pyridocarbazoles: Distinct Scaffolds for the Design of Selective Protein Kinase Inhibitors. J Org Chem. 2009 Dec 4;74(23):8997-9009.
  122. Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML. Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21167-72. Epub 2009 Nov 25.
  123. Sivendran S, Jones V, Sun D, Wang Y, Grzegorzewicz AE, Scherman MS, Napper AD, McCammon JA, Lee RE, Diamond SL, McNeil M. Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg Med Chem. 2009 Nov 20.
  124. Leszczynska K, Namiot A, Fein DE, Wen Q, Namior Z, Savage PB, Diamond SL, Janmey PA and Bucki R. Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice. BMC Microbiology, in press.
  125. Neeves K, Illing DAR, and Diamond SL. Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow. Biophysical Journal, in press.

COLLECTED PUBLICATIONS

Diamond Publications: 1989-1994

Diamond Publications: 1995-1996

Diamond Publications: 1997-2000

Diamond Publications: 2001-2003

Diamond Publications: 2004-2005

Diamond Publications: 2006-2008

Diamond Publications: 2009-Present

PATENTS

  1. Inventor: S. L. Diamond, J. H. Wu, and State University of New York at Buffalo. "Rapid assay of activators and inhibitors of clotting" U.S. Patent Number 5,567,596 (Filed: Dec. 29, 1994. Issued: Oct. 22, 1996).
  2. Inventor: S. L. Diamond, J. H. Wu, and State University of New York at Buffalo. "Method for assaying components in an enzyme-protein substrate system" U.S. Patent Number 5,786,137 (Filed: Aug. 15, 1996. Issued: July 28, 1998).
  3. Inventor: S. L. Diamond, and University of Pennsylvania. "Peptide Scaffolds for Transfer of Molecules into Eukaryotic Cells”. U.S. Patent Number 6,927,278. (Filed: April 25, 2001; Issued: Aug. 9, 2005).
  4. Inventor: S. L. Diamond and University of Pennsylvania. “Peptide scaffolds for transfer of molecules into eukaryotic cells” U.S. Patent Number 7,244,704. (Filed: February 16, 2005. Issued: July 17, 2007).
  5. Inventor: S. L. Diamond, D. Gosalia and University of Pennsylvania. “Method and devices for running reactions on a target plate for MALDI mass spectrometry” U.S. Patent Number 7,297,501. (Filed: December 15, 2004. Issued: November 20, 2007).
  6. Inventor: S. L. Diamond and University of Pennsylvania. “Peptide or protein microassay method and apparatus” U.S. Patent Number 7,332,286. (Filed: November 7, 2001. Issued: February 19, 2008).

PUBCHEM BIOASSAYS (Click here to retrieve full PubChem listing)

  1. AID: 523 Cathepsin B Inhibitor Series SAR Study
  2. AID: 581 Cathepsin G
  3. AID: 538 Complement factor C1s
  4. AID: 501 Cathepsin S
  5. AID: 830 Cathepsin B mixture HTS dose-response confirmation
  6. AID: 1696 Rml C and D fluorescent artifact dose-response confirmation
  7. AID: 1695 Rml C and D dose-response confirmation
  8. AID: 1230 E3 Ligase HTS_1536
  9. AID: 1533 Rml C and D inhibition 384-well mixture HTS from 1536-well compound plates
  10. AID: 1532 Rml C and D inhibition 384-well mixture HTS
  11. AID: 1394 E3 Ligase dose-response_384
  12. AID: 1444 E3 Ligase_WT_Dose Response
  13. AID: 1431 Kallikrein 5 1536 HTS Dose Response Confirmation
  14. AID: 1437 Homologous recombination_Rad 51_dose response_2
  15. AID: 1436 Homologous Recombination_Rad51_DNA binding assay
  16. AID: 1435 Homologous Recombination - Rad 51_Dose response
  17. AID: 1385 Homologous recombination - Rad 51
  18. AID: 1442 E3 Ligase_Mutant_Dose Response
  19. AID: 873 Kallikrein 5 1536 HTS
  20. AID: 852 Factor XIIa 1536 HTS Dose Response Confirmation
  21. AID: 846 Factor XIa 1536 HTS Dose Response Confirmation
  22. AID: 1215 Thrombin 1536 HTS Dose Response Confirmation
  23. AID: 1235 Alternative Pathway ELISA_orthogonal screening
  24. AID: 1046 Thrombin 1536 HTS
  25. AID: 834 C. albicans biofilm killing
  26. AID: 829 Complement C1s ELISA
  27. AID: 800 Factor XIIa 1536 HTS
  28. AID: 798 Factor XIa 1536 HTS
  29. AID: 792 eIF2B IC50 against mutant and WT yeast
  30. AID: 787 Complement factor C1s IC50 from mixture screen
  31. AID: 728 Factor XIIa Dose Response Confirmation from Single Well HTS
  32. AID: 721 Factor XIa Dose Response Confirmation from Single Well Screen
  33. AID: 716 Factor XIIa Dose Response Confirmation
  34. AID: 688 Yeast eIF2B assay
  35. AID: 687 Factor XIa Single Well HTS
  36. AID: 685 Yeast Toxicity Assay.
  37. AID: 680 Factor XIa Mixture HTS
  38. AID: 679 Factor XIa Dose Response Confirmation
  39. AID: 559 RNA polymerase
  40. AID: 460 Cathepsin L
  41. AID: 453 Cathepsin B
  42. AID: 1242 C. albicans biofilm killing---Mixture HTS
  43. AID: 701 Factor XIIa Single Well HTS
  44. AID: 488 Cathepsin B compound mixture screening
  45. AID: 1636 Cathepsin L probe #2 dose-response testing
  46. AID: 1633 Cathepsin L probe dose-response testing
  47. AID: 1627 Cathepsin L dose-response testing in the presence of cysteine
  48. AID: 691 Zebrafish Lipid Metabolism Assay - Dose-Response Confirmation.
  49. AID: 1392 RNA polymerase SAR
  50. AID: 832 Cathepsin G dose-response confirmation
  51. AID: 820 Cathepsin B dose-response confirmation
  52. AID: 684 Factor XIIa Mixture HTS
  53. AID: 825 Cathepsin L dose-response confirmation
  54. AID: 826 RNA polymerase dose-response confirmation
  55. AID: 831 Cathepsin S dose-response confirmation
  56. AID: 686 Zebrafish Lipid Metabolism Assay---Primary Screen
  57. AID: 370 Cytotoxicity assay human pulmonary artery cells
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spacer Institute of Medicine & Engineering (IME) spacer|spacer Biotech spacer|spacer BE spacer|spacer CBE spacer|spacer EMTM spacer|spacer Penn Center for Molecular Discovery spacer|spacer Blood Systems Biology spacer


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