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Mechanobiology
Thrombolysis
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Publications

  1. S. L. Diamond, S. G. Eskin, and L. V. McIntire, "Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells," Science 243, 1483 (1989).
  2. J. B. Sharefkin, S. L Diamond, C. W. Dieffenbach, and S. G. Eskin. "Effects of Sustained Laminar Shear Stress on Tissue Plasminogen Activator Levels," In: Cardiovascular Science and Technology (J. Norman, editor) Oxymoron Press, Louisville, p. 81 (1989).
  3. S. L. Diamond, J. B. Sharefkin, S. G. Eskin, C. Dieffenbach, K. Frasier-Scott, and L. V. McIntire, "Tissue Plasminogen Activator Messenger RNA Levels Increase in Cultured Human Endothelial Cells Exposed to Laminar Shear Stress," J. Cell. Physiol. 143, 364 (1990).
  4. J. B. Sharefkin, S. L. Diamond, S. G. Eskin, C. Dieffenbach, and L. V. McIntire, "Fluid Flow Decreases Endothelin mRNA Levels and Suppresses Endothelin Peptide Release in Human Endothelial Cells," J. Vasc. Surg. 14, 1 (1991).
  5. S. L.Diamond, J. B.Sharefkin, C. W. Dieffenbach, S. G.Eskin, and L. V. McIntire, "Regulation of Endothelial Cell Gene Expression by Hemodynamic Forces: Implications for Intimal Hyperplasia and Graft Patency," In: Technologies in Vascular Surgery, W. B. Saunders, Philadelphia (J. S. T. Yao and W. H. Pearce, eds.) p. 12-24 (1991).
  6. M. U. Nollert, S. L. Diamond, and L. V. McIntire, "Hydrodynamic Shear Stress and Mass Transport Modulation of Endothelial Cell Metabolism," Biotech. Bioengr. 38, 588 (1991).
  7. W. Sigurdson, F. Sachs, and S. L. Diamond, "Mechanical Perturbation of Cultured Human Endothelial Cells Causes Rapid Increases of Intracellular Calcium." Amer. J. Physiology 264, H1745 (1993).
  8. M.Yamaguchi, S. L. Diamond, H. Watanabe, H. Gallati, W. Baur, and J. B. Sharefkin. Heparin and Dibutyryl cAMP Modulate Gene Expression in Stimulated Human Saphenous Vein Smooth Muscle Cells. In Vitro Cell. Devel. Biol. 29, 863 (1993).
  9. S. L. Diamond and S. Anand, "Inner Clot Diffusion and Permeation During Fibrinolysis," Biophysical J. 65, 2622 (1993).
  10. V. Ranjan and S. L. Diamond, "Fluid Shear Stress Induces Synthesis and Nuclear Localization of c-Fos in Cultured Human Endothelial Cells," Biochem. Biophys. Res. Comm. 196, 79 (1993).
  11. J. H. Wu, K. A. Siddiqui, and S. L. Diamond. "Transport Phenomena and Clot Dissolving Therapy: An Experimental Investigation of Diffusion-Controlled and Permeation-Enhanced Fibrinolysis." Thrombosis Haemostasis 72, 105 (1994).
  12. S. L. Diamond, F. Sachs, and W. J. Sigurdson. "The Mechanically-Induced Calcium Mobilization in Cultured Endothelial Cells is Dependent on Actin and Phospholipase," Arteriosclerosis Thrombosis 14, 2000 (1994).
  13. S. L. Diamond and A. I. Kozak, "A Course in Biotechnology and Society," Chemical Engineering Education 28, 140 (1994).
  14. J. H. Wu and S. L. Diamond, "A Fluorescence Quench and Dequench Assay for Fibrinogen Polymerization, Fibrinogenolysis, or Fibrinolysis," Analytical Biochem. 224, 83 (1995).
  15. S. L. Diamond and L. V. McIntire, "Gene Regulation in Endothelial Cells," In: Flow Dependent Regulation of Vascular Function in Health and Disease," Oxford University Press, New York (J. A. Beven, G. Kaley, G. M. Rubanyi, eds.) Chapter 4. p. 62-84 (1995).
  16. J. H. Wu and S. L. Diamond. "Tissue Plasminogen Activator Inhibits Plasmin Degradation of Fibrin: A Mechanism that Slows tPA-mediated Fibrinolysis but Does Not Require 2-antiplasmin or Leakage of Intrinsic Plasminogen," J. Clinical Investigation 95, 2483 (1995).
  17. V. Ranjan, S. Z. Xiao, and S. L. Diamond. "Constitutive NOS Expression in Cultured Endothelial Cells is Elevated by Fluid Shear Stress." Amer. J. Physiol. 268, H550 (1995).
  18. J. H. Wu and S. L. Diamond. "Fluorogenic Fibrinogen and Fibrin Facilitate Macromolecular Assembly and Dynamic Measurement of Picomolar Levels of Plasminogen Activators under Well Mixed Conditions." Thrombosis Haemostasis 74, 711 (1995).
  19. S. Anand, J. H. Wu, and S. L. Diamond. "Enzyme Mediated Proteolysis of Fibrous Biopolymers: Dissolution Front Movement in Fibrin or Collagen under Conditions of Diffusive or Convective Transport." Biotech. Bioeng. 48, 89 (1995).
  20. V. Ranjan, R. Waterbury, and S. L. Diamond. "Fluid Shear Stress Induction of the Transcriptional Activator c-fos in Human and Bovine Endothelial Cells, HeLa, and CHO Cells." Biotech. Bioeng. 49, 383 (1996).
  21. S. Anand and S. L. Diamond. "Computer Simulation of Systemic Circulation and Clot Lysis Dynamics During Thrombolytic Therapy That Accounts for Inner Clot Transport and Reaction." Circulation. 94, 763 (1996).
  22. D.S. Vaidya, J.M. Nitsche, S.L. Diamond, D.A. Kofke. "Convection-Diffusion of Solutes in Dynamic Media" Adsorption 3, 41 (1996).
  23. D.S. Vaidya, J.M. Nitsche, S.L. Diamond, D.A. Kofke. "Convection-Diffusion of Solutes in Media with Piecewise Constant Transport Properties." Chem. Eng. Sci. 51, 5299 (1996).
  24. A. Subramanian, S.L. Diamond. "Enhancement of nonviral gene transfer to endothelial cells using lipofection of histone complexed DNA," Tissue Engineering 3, 39 (1997).
  25. D.S. Vaidya, J.M. Nitsche, S.L. Diamond, D.A. Kofke. "Perturbation Solution to the Convection-Diffusion Equation with Moving Fronts." AICHE J. 43, 631 (1997).
  26. Z. Xiao, X. Zhang, S.L. Diamond. "Shear stress induction of endothelial nitric oxide synthase is calcium-dependent, but not calcium-activated." J. Cell. Physiol. 171, 205 (1997).
  27. W. Wang, S.L. Diamond. Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells? Biochem. Biophys. Res. Comm. 233, 748 (1997).
  28. D.S. Vaidya, S.L. Diamond, J.M. Nitsche D.A. Kofke. "Potential for use of liquid crystals as dynamically tunable electrophoretic media." AICHE J. 43, 1366 (1997).
  29. S. Anand, V. Kudallur, B. Pitman, S. L. Diamond. "Mechanisms by which thrombolytic therapy results in nonuniform lysis and residual thrombus after reperfusion." Ann. Biomed. Engr. 25, 964 (1997).
  30. S. L. Diamond. "Engineering Approaches for Thrombolytic Therapy" BMES Bulletin. 21, 3 (1997).
  31. P. Tandon, S. L. Diamond. "Hydrodynamic effects and receptor interactions of platelets and their aggregates in linear shear flow." Biophysical J. 73, 2819 (1997).
  32. P. Tandon, S. L. Diamond. "Kinetics of b2-integrin and L-selectin bonding during neutrophil aggregation in shear flow." Biophysical J. 75, 3163 (1998).
  33. W. J. Calvo, G. Hajduczok, J.A. Russell, and S.L. Diamond. "Inhibition of nitric oxide but not prostacyclin prevents poststenotic dilatation in rabbit femoral artery." Circulation. 99, 1069 (1999).
  34. S. L. Diamond. "Engineering Design of Optimal Strategies for Blood Clot Dissolution" Annual Reviews of Biomedical Engineering. 1, 27 (1999).
  35. Z. Zhang, Z. Ziao, and S. L. Diamond. "Shear stress induction of C-type natriuretic peptide (CNP) in endothelial cells is independent of NO autocrine signaling" Annals Biomed. Engr. 27, 419 (1999).
  36. I. Laurenzi, S. L. Diamond. "Monte Carlo solution of heterotypic aggregation kinetics of platelets and neutrophils." Biophysical J. 77, 1733 (1999).
  37. A. Subramanian, P. Ranganathan, S. L. Diamond. "Nuclear targeting peptide scaffold for lipofection of nondividing mammalian cells." Nature Biotechnology. 17, 873 (1999).
  38. S. L. Diamond, P. Tandon, D. Schmidtke, I. Laurenzi. "Cellular Aggregation in Blood Flow." Comments Theoretical Biol. 8, 1 (2000).
  39. S. L. Diamond. "Intracellular Receptors--Steroid Receptors and Nitric Oxide." Animal Plant Cell Tech. 7, 1097 (2000).
  40. D. Schmidtke, S. L. Diamond. "Direct observation of membrane tethers formed during neutrophil attachment to adherent platelets or P-selectin in physiological shear flow." J. Cell. Biol. 179, 719 (2000).
  41. J. M. Abrahams, S. L. Diamond, R. W. Hurst, E.L. Zager, M.S. Grady. Surface modifications Enhancing Biological Activity of Guglielmi Detachable Coils in Treating Intracranial Aneurysms. Surgical Neurology 54, 34 (2000).
  42. H. Ma, S.L. Diamond. Non-viral gene therapy and its delivery systems. Curr. Pharmaceut. Biot. 2, 1 (2001).
  43. S.L. Diamond. Reaction complexity in flowing human blood. Biophysical J. 80, 1031(2001).
  44. J. M. Abrahams, M.S. Forman, M. S. Grady, S. L. Diamond. Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model. Amer. J. Neuroradiology. 22,1410 (2001).
  45. J.M. Abrahams, M. S. Forman, M. S. Grady, and S. L. Diamond. Biodegradable polyglycolide endovascular coils promote wall thickening and drug delivery in a rat aneurysm model. Neurosurgery. 49, 1187 (2001).
  46. M. Goel, S.L. Diamond. Neutrophil enhancement of fibrin deposition under flow though platelet-independent and platelet-dependent mechanisms. Arteriol. Thromb. Vasc. Biol. 21, 2093 (2001).
  47. C.K. Byrnes, P. H. Nass, M. D. Duncan, S.L. Diamond, J. W. Harmon. Assessment of a nuclear targeting peptide scaffold (M9) to improve plasmid DNA transfection efficiency. Surg. Forum. 102, 538 (2001).
  48. A. Subramanian, H. Ma, K.N. Dahl, J. Zhu, and S.L. Diamond. Adenovirus or HA-2 peptide assisted lipofection increases cytoplasmic plasmid in nondividing endothelium with little enhancement of transgene expression. J. Gene Med. 4:75 (2002).
  49. I.J. Laurenzi, S.L. Diamond. Multicomponent Aggregation and Gel Formation via Simultaneous Convection and Diffusion. I.E.C.&R. 40: 413 (2002).
  50. E.Y.H. Park, M.J. Smith, E. S. Stropp, J. A. Diveietro, W. F. Walker, D.W. Schmidtke, S.L.Diamond, M.B. Lawrence. Comparison of PSGL-1 microbead and neutrophil rolling: Microvillus elongation stabilizes P-selectin clusters. Biophysical J. 82, 1835 (2002).
  51. JM. Abrahams, C Song, MS Grady, SL Diamond, RJ Levy. Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering. Stroke. 33, 1376 (2002).
  52. I.J. Laurenzi, J.D. Bartels, S.L. Diamond. A general algorithm for exact numerical simulation of multi-component aggregation. J. Comput. Phys. 177, 418 (2002).
  53. M. Frojmovic, G. Nash, S.L. Diamond. Cell Aggregation and Cell Adhesion in Flow. Thromb. Haem. 87, 771 (2002).
  54. H. Ma, J. Zhu, M. Maronski, V.M.Y. Lee, M. Dichter, S.L. Diamond. Nonclassical nuclear localization signal peptides for high efficiency lipofection of primary neurons and neuronal cell lines. Neuroscience 111, 1 (2002).
  55. T. A. Doggett, G. Girdhar, A. Lawshe, D. W. Schmidtke, I. J. Laurenzi, S. L. Diamond, T. G. Diacovo. Selectin-like Kinetics and Biomechanics Promote Rapid Platelet Adhesion in Flow: The GPIb?-vWF Tether Bond. Biophysical J. 83, 194 (2002).
  56. M. Goel, S. L. Diamond. Adhesion of normal erythrocytes to activated neutrophils, activated platelets, and fibrin polymerized from plasma at depressed venous shear rates. Blood. 100, 3739 (2002).
  57. E. A. Pierce, Q. Liu, O. Igoucheva, H.Ma, R. Omarrudin, S. L. Diamond, K. Yoon. Oligonucleotide-directed single base DNA alterations in mouse embryonic stem cells. Gene Therapy. 10:24 (2003).
  58. M.Goel, S.L. Diamond. Neutrophil cathepsin G enhances prothrombinase and fibrin formation under flow by activating fibrinogen-adherent platelets. J. Biol. Chem. 278, 9458 (2003).
  59. J. Y. Ji, H. Jing, S. L. Diamond. Shear stress enhances nuclear localization of endothelial glucocorticoid receptor and expression from the GRE promoter. Circ. Res. 92, 279 (2003).
  60. I.J. Laurenzi, S.L. Diamond. Kinetics of Reversible Aggregation and Gelation with Multiple Components. Phys. Rev. E. 67, 51103 (2003).
  61. T.A. Doggett, G. Girdhar, A. Lawshe, J.L. Miller, I.J. Laurenzi, S.L. Diamond, T.G. Diacovo. Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val.. Blood 102, 152 (2003).
  62. D. Gosalia, S.L. Diamond. Printing chemical libraries for nanoliter fluid phase reactions. Proc. Natl. Acad. Sci. USA (Track II) 100, 8721 (2003).
  63. D. M. Eckmann, S.L. Diamond. Surfactants attenuate gas embolism-induced thrombin production. Anesthesiology 100, 77 (2004).
  64. H. Ma, Q. Liu, S.L. Diamond, and E.A. Pierce. Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency. Methods. 33:113 (2004).
  65. J. Gruneich, A. R. Price, H. Jing, S. L. Diamond. Cationic corticosteroid for nonviral gene delivery. Gene Therapy 11:668 (2004).
  66. M. Goel, S. L. Diamond. Thrombosis. Encyclopedia of Biomaterials and Biomedical Engineering. Eds. G. E. Wnek, G. L. Bowlin. Marcel Dekker. (2004).
  67. J. M. Abrahams, S. L. Diamond. Biological and Future Management of Aneuryms. In "Management of Cerebral Aneurysms." Eds. P.D. LeRoux and H.R. Winn. Elsevier Science. (2004).
  68. K.A. Kadash, M.B. Lawrence, S.L. Diamond. Neutrophil String Formation: Hydrodynamic thresholding and cell deformation during cell collisions. Biophysical J. 86:(2004).
  69. M. Goel, S. L. Diamond. Factor VIIa-mediated tenase function on activated platelets under flow. J. Thromb. Haem. 2:1402 (2004).
  70. J. Ji, S. L. Diamond. Exogenous nitric oxide activates the endothelial glucocorticoid receptor. Biochem. Biophys. Res. Comm. 318:192 (2004).
  71. K. Lo and S. L. Diamond. Blood coagulation kinetics: High throughput method for realtime reaction monitoring. Thromb. Haem. 92:874 (2004).
  72. H. Ma, K. Y. Horiuchi, Y. Wang, S. A. Kucharewicz, S. L. Diamond. Nanoliter Homogeneous Ultra High Throughput Screening Microarray for Lead Discoveries and IC50 Profiling. Assay & Drug Develop.Tech.. 3:177 (2005).
  73. A. Price, M. Limberis, J. Gruneich, J. M. Wilson, S. L. Diamond. Targeting viral-mediated transduction to the lung airway epithelium with the anti-inflammatory cationic lipid dexamethasone-spermine. Molecular Therapy. 12:502 (2005).
  74. Edmondson KE, Denney WS, Diamond SL: Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime. Biophys J 2005, 89:3603-3614.
  75. Gosalia DN, Salisbury CM, Ellman JA, Diamond SL: High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays. Mol Cell Proteomics 2005, 4:626-636.
  76. Gosalia DN, Salisbury CM, Maly DJ, Ellman JA, Diamond SL: Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays. Proteomics 2005, 5:1292-1298.
  77. Lo K, Denney WS, Diamond SL: Stochastic modeling of blood coagulation initiation. Pathophysiol Haemost Thromb 2005, 34:80-90.
  78. Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P: Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. Proc Natl Acad Sci U S A 2005, 102:11876-11881.
  79. Ganguly K, Goel MS, Krasik T, Bdeir K, Diamond SL, Cines DB, Muzykantov VR, Murciano JC: Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo. J Pharmacol Exp Ther 2006, 316:1130-1136.
  80. Gosalia DN, Denney WS, Salisbury CM, Ellman JA, Diamond SL: Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray. Biotechnol Bioeng 2006, 94:1099-1110.
  81. Horiuchi KY, Wang Y, Diamond SL, Ma H: Microarrays for the functional analysis of the chemical-kinase interactome. J Biomol Screen 2006, 11:48-56.
  82. Kim MS, Diamond SL: Controlled release of DNA/polyamine complex by photoirradiation of a solid phase presenting o-nitrobenzyl ether tethered spermine or polyethyleneimine. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5572-5.
  83. Kim MS, Diamond SL: Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications. Bioorg Med Chem Lett 2006, 16:4007-4010.
  84. Murphy BR, Moayedpardazi HS, Gewirtz AM, Diamond SL, Pierce EA: Delivery and mechanistic considerations for the production of knock-in mice by single-stranded oligonucleotide gene targeting. Gene Ther. 2007 Feb;14(4):304-15.
  85. Okorie UM, Diamond SL: Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow. Biophys J. 2006 Nov 1;91(9):3474-81.
  86. Diamond SL:. Methods for mapping protease specificity. Curr Opin Chem Biol. 2007 Feb;11(1):46-51.
  87. Gruneich JA, Diamond SL: Synthesis and structure-activity relationship of a series of increasingly hydrophobic cationic steroid lipofection reagents. J. Gene Medicine 9 2007 May;9(5):381-91
  88. Handwerger RG and Diamond SL: Photolytic biotinylated PEI: Capture and triggered release of nucleic acids from solid supports. J. Bioconj. Chem. 2007 May-June;18(3):717-723
  89. Price AR, Limberis MP, Wilson JM, Diamond SL. Pulmonary delivery of adenovirus vector formulated with dexamethasone-spermine facilitates homologous vector re-administration. Gene Ther. 2007 No;14(22):1594-604
  90. Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB 3rd. Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4761-6. Epub 2007 Jul 5.
  91. Okorie UM, Denney WS, Chatterjee MS, Neeves KB, Diamond SL. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood. 2008 Jan 22;
  92. Myers MC, Shah PP, Diamond SL, Huryn DM, Smith AB 3rd. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.
    Bioorg Med Chem Lett. 2008 Jan 1;18(1):210-4. Epub 2007 Nov 1.
  93. de Almeida RA, Burgess D, Shema R, Motlekar N, Napper AD, Diamond SL, Pavitt GD. A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening. Yeast. 2008 Jan;25(1):71-6
  94. Neeves K and Diamond SL. A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood. Lab Chip, DOI: 10.1039 (in press)
  95. Ahn, Hyun Hee; Lee, Min Suk; Cho, Mi Hee; Shin, Yu Na; Lee, Jung Hwa; Kim, Kyung Sook; Kim, Moon Suk; Khang, Gilson; Hwang, Ki Chul; Lee, Il Woo; Diamond, Scott L.; Lee, Hai Bang. DNA/PEI nano-particles for gene delivery of rat bone marrow stem cells. Colloids and Surfaces A-Physiochemical and Engineering Aspects313: 116-120 Sp. Iss. SI FEB 1 2008

PATENTS

  1. Inventor: S. L. Diamond, J. H. Wu, and State University of New York at Buffalo. "Rapid assay of activators and inhibitors of clotting" U.S. Patent Number 5,567,596 (Filed: Dec. 29, 1994. Issued: Oct. 22, 1996).
  2. Inventor: S. L. Diamond, J. H. Wu, and State University of New York at Buffalo. "Method for assaying components in an enzyme-protein substrate system" U.S. Patent Number 5,786,137 (Filed: Aug. 15, 1996. Issued: July 28, 1998).
  3. Inventor: S. L. Diamond, and University of Pennsylvania. "Peptide Scaffolds for Transfer of Molecules into Eukaryotic Cells. U.S. Patent Number 6,927,278. (Filed: April 25, 2001; Issued: Aug. 9, 2005

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