Subramaniam S, Akay M, Anastasio MA, Bailey V, Boas D, Bonato P, Chilkoti A, Cochran JR, Colvin V, Desai TA, Duncan JS, Epstein FH, Fraley S, Giachelli C, Grande-Allen KJ, Green J, Guo XE, Hilton IB, Humphrey JD, Johnson CR, Karniadakis G, King MR, Kirsch RF, Kumar S, Laurencin CT, Li S, Lieber RL, Lovell N, Mali P, Margulies SS, Meaney DF, Ogle B, Palsson B, Peppas NA, Perreault EJ, Rabbitt R, Setton LA, Shea LD, Shroff SG, Shung K, Tolias AS, van der Meulen MCH, Varghese S, Vunjak-Novakovic G, White JA, Winslow R, Zhang J, Zhang K, Zukoski C, Miller MI. Grand challenges at the Interface of Engineering and Medicine. IEEE Open J Eng Med Biol 5, 1-13 (2024). (PDF)

Culkin MC, Coons M, Bele P, Thaploo A, Georges AP, Anderson E, Browne KD, Jacovides C, Santos P, Kaplan LJ, Meaney DF, Smith DH, Pascual JL. Delayed TXA after TBI impedes learning, memory; early TXA is favorable but not in sham animals. J Trauma Acute Care Surg 96, 26-34 (2024). (PDF)


O'Neill KM, Anderson ED, Mukherjee S, Gandu S, McEwan SA, Omelchenko A, Rodriguez AR, Losert W, Meaney DF, Babadi B, Firestein BL. Time-dependent homeostatic mechanisms underlie brain-derived neurotrophic factor action on neural circuitry. Commun Biol 6, 1278 (2023). (PDF)

Vemu R, Yane TK, Glova GS, Paglia PL, Okyan K, Meaney DF, Chreiman K, Kaplan LJ, Pascual JL. A simple engineering alteration to IO access device electronics can lead to improved placement accuracy confirmation. J Trauma Acute Care Surg (2023). (PDF)


Adegoke MA, Teter O, Meaney DF. Flexibility of in vitro cortical circuits influences resilience from microtrauma. Front Cell Neurosci 16, 991740 (2022). (PDF)

Schumm SN, Gabrieli D, Meaney DF. Plasticity impairment alters community structure but permits successful pattern separation in a hippocampal network model. Front Cell Neurosci 16, 977769 (2022). (PDF)

Wu T, Rifkin JA, Rayfield AC, Anderson ED, Panzer MB, Meaney DF. Concussion Prone Scenarios: A Multi-Dimensional Exploration in Impact Directions, Brain Morphology, and Network Architectures Using Computational Models. Ann Biomed Eng 50, 1423-1436 (2022). (PDF)

Rifkin JA, Wu T, Rayfield AC, Anderson ED, Panzer MB, Meaney DF. Brain architecture-based vulnerability to traumatic injury. Front Bioeng Biotechnol 10 (2022). (PDF)

Song H, Chen C, Kelley B, Tomasevich A, Lee H, Dolle J, Cheng J, Garcia B, Meaney DF, Smith DH. Traumatic brain injury recapitulates developmental changes of axons. Prog Neurobiol 217, 102332 (2022). (PDF)

Shin SS, Hefti MM, Mazandi VM, Issadore DA, Meaney DF, Schneider ALC, Diaz-Arrastia R, Kilbaugh TJ. Plasma Neurofilament Light and Glial Fibrillary Acidic Protein Levels over Thirty Days in a Porcine Model of Traumatic Brain Injury. J Neurotrauma 39, 13-14 (2022). (PDF)

Schroeder ME, Bassett DS, Meaney DF. A multilayer network model of neuron-astrocyte populations in vitro reveals mGluR5 inhibition is protective following traumatic injury. Netw Neurosci 6, 2 (2022). (PDF)

Yang Z, Atiyas Y, Shen H, Siedlik MJ, Wu J, Beard K, Fonar G, Dolle JP, Smith DH, Eberwine JH, Meaney DF, Issadore DA. Ultrasensitive Single Extracellular Vesicle Detection Using High Throughput Droplet Digital Enzyme-Linked Immunosorbent Assay. Nano Lett 22, 11 (2022). (PDF)

Wu T, Rifkin JA, Rayfield A, Panzer MB, Meaney DF. An interdisciplinary computational model for predicting traumatic brain injury: Linking biomechanics and functional neural networks. Neuroimage 251, 119002 (2022). (PDF)

Schumm SN, Gabrieli D, Meaney DF. Plasticity impairment exposes CA3 vulnerability in a hippocampal network model of mild traumatic brain injury. Hippocampus 32, 231-250 (2022). (PDF)

Billiar K, Gaver DP 3rd, Barbee K, Singh A, DesJardins JD, Pruitt B, Tranquillo J, Gaudette G, Winkelstein B, Makowski L, Amos JR, Saterbak A, LeDoux J, Helmke B, Grimm M, Benkeser P, Segan LD, Pfister B, Meaney D, Arinzeh T, Margulies S. Learning Environments and Evidence-Based Practices in Bioengineering and Biomedical Engineering. Biomed Eng Educ 2, 1 (2022). (PDF)


Beard K, Yang Z, Haber M, Flamholz M, Diaz-Arrastia R, Sandsmark D, Meaney DF, Issadore. Extracellular vesicles as distinct biomarker reservoirs for mild traumatic brain injury diagnosis. Brain Commun 3, fcab151 (2021). (PDF)

Mott RE, von Reyn CR, Firestein BL, Meaney DF. Regional Neurodegeneration in vitro: The Protective Role of Neural Activity. Front Comp Neurosci 15, 580107 (2021). (PDF)

Smith DH, Dollé J-P, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati L-N, Hinds SR, Iacono D, Johnson VE, Keene CD, Kofler J, Kovacs GG, Lee EB, Manley G, Meaney DF, Montine T, Okonkwo DO, Perl DP, Trojanowski JQ, Wiebe DJ, Yaffe K, McCabe, T, Stewart W. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathol Commun 9, 32 (2021). (PDF)

Rodriguez AR, Anderson ED, O'Neill KM, McEwan PP, Vigilante NF, Kwon M, Akum BF, Stawicki TM, Meaney DF, Firestein BL. Cytosolic PSD-95 Interactor Alters Functional Organization of Neural Circuits and AMPA Receptor Signaling Independent of PSD-95 Binding. Netw Neurosci 5, 166-197 (2021). (PDF)

Saikumar J, Kim J, Byrns CN, Hemphill M, Meaney DF, Bonini NM. Inducing Different Severities of Traumatic Brain Injury in Drosophila Using a Piezoelectric Actuator. Nat Protoc 16, 263-282 (2021). (PDF)

Gabrieli D, Schumm SN, Vigilante NF, Meaney DF. NMDA Receptor Alterations After Mild Traumatic Brain Injury Induce Deficits in Memory Acquisition and Recall. Neural Comp 33, 67-95 (2021). (PDF)


Gabrieli D, Schumm SN, Vigilante NF, Parvesse B, Meaney DF. Neurodegeneration Exposes Firing Rate Dependent Effects on Oscillation Dynamics in Computational Neural Networks. PLoS ONE 15, 9 (2020). (PDF)

Tummala SR, Hemphill MA, Nam A, Meaney DF. Concussion Increases CA1 Activity During Prolonged Inactivity in a Familiar Environment. Exp Neurol 334, 113435 (2020). (PDF)

Saikumar J, Byrns CN, Hemphill M, Meaney DF, Bonini NM. Dynamic Neural and Glial Responses of a Head-Specific Model for Traumatic Brain Injury in Drosophila. PNAS 117, 17269-17277 (2020). (PDF)

Anderson ED, Giudice JS, Wu T, Panzer MB, Meaney DF. Predicting Concussion Outcome by Integrating Finite Element Modeling and Network Analysis. Front Bioeng Biotechnol 8, 309 (2020). (PDF)

Ko J, Hemphill M, Yang Z, Beard K, Sewell E, Shallcross J, Schweizer M, Sandsmark DK, Diaz-Arrastia R, Kim J, Meaney DF, Issadore DA. Multi-dimensional mapping of brain-derived extracellular vesicle (EV) miRNA biomarker for traumatic brain injury diagnostics. J Neurotrauma 37, 2424-2434 (2020). (PDF)

Beard K, Meaney DF, Issadore D. Clinical Applications of Extracellular Vesicles in the Diagnosis and Treatment of Traumatic Brain Injury. J Neurotrauma 37, 2045-2056 (2020). (PDF)

Gabrieli D, Vigilante NF, Scheinfeld R, Rifkin JA, Schumm SN, Wu T, Gabler LF, Panzer MB, Meaney DF. A Multibody Model for Predicting Spatial Distribution of Human Brain Deformation Following Impact Loading. J Biomech Eng 142, 091015 (2020). (PDF)

Schumm SN, Gabrieli D, Meaney DF. Neuronal Degeneration Impairs Rhythms Between Connected Microcircuits. Front Comput Neurosci 14, 18 (2020). (PDF)


Vogel EW 3rd, Panzer MB, Morales FN, Varghese N, Bass CR, Meaney DF, Morrison B 3rd. Direct Observation of Low Strain, High Rate Deformation of Cultured Brain Tissue During Primary Blast. Ann Biomed Eng 47, 1-11 (2019). (PDF)

Omelchenko A, Shrirao AB, Bhattiprolu AK, Zahn JD, Schloss RS, Dickson S, Meaney DF, Boustany NN, Yarmush ML, Firestein BL. Dynamin and reverse-mode sodium calcium exchanger blockade confers neuroprotection from diffuse axonal injury. Cell Death Dis 10, 727 (2019). (PDF)

Patel MV, Sewell E, Dickson S, Kim H, Meaney DF, Firestein BL. A Role for Postsynaptic Density 95 and Its Binding Partners in Models of Traumatic Brain Injury. J Neurotrauma 36, 2129–2138 (2019). (PDF)

LaPlaca MC, Lessing MC, Prado GR, Zhou R, Tate CC, Geddes-Klein D, Meaney DF, Zhang L. Mechanoporation is a potential indicator of tissue strain and subsequent degeneration following experimental traumatic brain injury. Clinical Biomechanics 64, 2-13 (2019). (PDF)

Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AIR, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH. Primum non nocere: a call for balance when reporting on CTE. The Lancet Neurology 18 (3), 231-233 (2019). (PDF)


Ko J, Hemphill M, Yang Z, Sewell E, Na YJ, Sandsmark DK, Haber M, Fisher SA, Torre EA, Svane KC, Omelchenko A, Firestein BL, Diaz-Arrastia R, Kim J, Meaney DF, Issadore D. Diagnosis of traumatic brain injury using miRNA signatures in nanomagnetically isolated brain-derived extracellular vesicles. Lab Chip 18 (23), 3617-3630 (2018). (PDF)

Swiatkowski P, Sewell E, Sweet ES, Dickson S, Swanson RA, McEwan SA, Cuccolo N, McDonnell ME, Patel MV, Varghese N, Morrison B, Reitz AB, Meaney DF, Firestein BL. Cypin: A novel target for traumatic brain injury. Neurobiol Dis 119, 13–25 (2018). (PDF)

DeWitt DS, Hawkins BE, Dixon CE, Kochanek PM, Armstead W, Bass CR, Bramlett HM, Buki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds SR, LaPlaca MC, Long JB, Meaney DF, Mondello S, Noble-Haeusslein LJ, Poloyac SM, Prough DS, Robertson CS, Saatman KE, Shultz SR, Shear DA, Smith DH, Valadka AB, VandeVord P, Zhang L. Pre-clinical testing of therapies for traumatic brain injury. J Neurotrauma neu.2018.5778 (2018). (PDF)

Johnson VE, Weber MT, Xiao R, Cullen DK, Meaney DF, Stewart W, Smith DH. Mechanical disruption of the blood–brain barrier following experimental concussion. Acta Neuropathol. 135 (5), 711-726 (2018). (PDF)


Vogel EW 3rd, Morales FN, Meaney DF, Bass CR, Morrison B 3rd. Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast. Exp Neurol 293, 91–100 (2017). (PDF)

Wiles L, Gu S, Pasqualetti F, Parvesse B, Gabrieli D, Bassett DS, Meaney DF. Autaptic connections shift network excitability and bursting. Sci Rep 7, 44006 (2017). (PDF)

Vogel EW 3rd, Rwema SH, Meaney DF, Bass CR, Morrison B 3rd. Primary blast injury depressed hippocampal long-term potentiation through disruption of synaptic proteins. J Neurotrauma 34, 1063–1073 (2017). (PDF)


Effgen GB, Ong T, Nammalwar S, Ortuño AI, Meaney DF, Bass CR, Morrison B 3rd. Primary blast exposure increases hippocampal vulnerability to subsequent exposure: Reducing long-term potentiation. J Neurotraum 33 (20), 1901-1912 (2016). (PDF)

Cullen DK, Harris JP, Browne KD, Wolf JA, Duda JE, Meaney DF, Margulies SS, Smith DH. A porcine model of traumatic brain injury via head rotational acceleration. Meth Mol Bio 1462, 289–324 (2016). (PDF)

Ko J, Hemphill MA, Gabrieli D, Wu L, Yelleswarapu V, Lawrence G, Pennycooke W, Singh A, Meaney DF, Issadore D. Smartphone-enabled optofluidic exosome diagnostic for concussion recovery. Sci Rep 6, 31215 (2016). (PDF)

Beamer M, Tummala SR, Gullotti D, Kopil C, Gorka S, Ted Abel, Bass CR, Morrison B 3rd, Cohen AS, Meaney DF. Primary blast injury causes cognitive impairments and hippocampal circuit alterations. Exp Neurol 283, 16–28 (2016). (PDF)

Hue CD, Cho FS, Cao S, Nicholls RE, Vogel Iii EW, Sibindi C, Arancio O, Dale Bass CR, Meaney DF, Morrison B 3rd. Time course and size of blood–brain barrier opening in a mouse model of blast-induced traumatic brain injury. J Neurotrauma 33 (13), 1202-11 (2016). (PDF)

Vogel EW 3rd, Effgen GB, Patel TP, Meaney DF, Bass CR, Morrison B 3rd. Isolated primary blast inhibits long-term potentiation in organotypic hippocampal slice cultures. J Neurotrauma 33, 652–661 (2016). (PDF)


Hue CD, Cho FS, Cao S, Dale Bass CR, Meaney DF, Morrison B 3rd. Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein. J Cereb Blood Flow Metab 35, 1191–1198 (2015). (PDF)

Johnson VE, Meaney DF, Cullen DK, Smith DH. Animal models of traumatic brain injury. Handb Clin Neurol 127, 115–28 (2015). (PDF)

Meaney DF, Smith DH. Cellular biomechanics of central nervous system injury. Handb Clin Neurol 127, 105–114 (2015). (PDF)

Patel TP, Man K, Firestein BL, Meaney DF. Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging. J Neurosci Methods 243, 26–38 (2015). (PDF)

Kang WH, Cao W, Graudejus O, Patel TP, Wagner S, Meaney DF, Morrison B 3rd. Alterations in hippocampal network activity after in vitro traumatic brain injury. J Neurotrauma 32 (13), 1011-9 (2015). (PDF)


Patel TP, Gullotti DM, Hernandez P, O'Brien WT, Capehart BP, Morrison B 3rd, Bass C, Eberwine JE, Abel T, Meaney DF. An open-source toolbox for automated phenotyping of mice in behavioral tasks. Front Behav Neurosci 8, 349 (2014). (PDF)

Chen Y, Mao H, Yang KH, Abel T, Meaney DF. A modified controlled cortical impact technique to model mild traumatic brain injury mechanics in mice. Front Neurol 5, 100 (2014). (PDF)

Gullotti DM, Beamer M, Panzer MB, Chen YC, Patel TP, Yu A, Jaumard N, Winkelstein B, Bass CR, Morrison B, Meaney DF. Significant head accelerations can influence immediate neurological impairments in a murine model of blast-induced traumatic brain injury. J Biomech Eng 136, 091004 (2014). (PDF)

Patel TP, Ventre SC, Geddes-Klein D, Singh PK, Meaney DF. Single-neuron NMDA receptor phenotype influences neuronal rewiring and reintegration following traumatic injury. J Neurosci 34, 4200–4213 (2014). (PDF)

Effgen GB, Vogel EW 3rd, Lynch KA, Lobel A, Hue CD, Meaney DF, Bass CR, Morrison B 3rd. Isolated primary blast alters neuronal function with minimal cell death in organotypic hippocampal slice cultures. J Neurotrauma 31(13),1202-10 (2014). (PDF)

Meaney DF, Morrison B, Bass CR. The mechanics of traumatic brain injury: A review of what we know and what we need to know for reducing its societal burden. J Biomech Eng 136, 021008 (2014). (PDF)

Hue CD, Cao S, Bass CR, Meaney DF, Morrison B 3rd. Repeated primary blast injury causes delayed recovery, but not additive disruption, in an in vitro blood–brain barrier model. J Neurotrauma 31, 951–960 (2014). (PDF)


Weerakkody TN, Patel TP, Yue C, Takano H, Anderson HC, Meaney DF, Coulter DA, Wolfe JH. Engraftment of nonintegrating neural stem cells differentially perturbs cortical activity in a dose-dependent manner. Mol Ther 21, 2258–2267 (2013). (PDF)

Hue CD, Cao S, Haider SF, Vo KV, Effgen GB, Vogel E 3rd, Panzer MB, Bass CR, Meaney DF, Morrison B 3rd. Blood-brain barrier dysfunction after primary blast injury in vitro. J Neurotrauma 30, 1652–1663 (2013). (PDF)

Schoch KM, von Reyn CR, Bian J, Telling GC, Meaney DF, Saatman KE. Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse. J Neurochem 125, 909–920 (2013). (PDF)

Choo AM, Miller WJ, Chen YC, Nibley P, Patel TP, Goletiani C, Morrison B 3rd, Kutzing MK, Firestein BL, Sul JY, Haydon PG, Meaney DF. Antagonism of purinergic signalling improves recovery from traumatic brain injury. Brain 136, 65–80 (2013). (PDF)


Panzer MB, Matthews KA, Yu AW, Morrison B 3rd, Meaney DF, Bass CR. A multiscale approach to blast neurotrauma modeling: Part I – Development of novel test devices for in vivo and in vitro blast injury models. Front Neurol 3, 46 (2012). (PDF)

Mesfin MN, von Reyn CR, Mott RE, Putt ME, Meaney DF. In vitro stretch injury induces time- and severity-dependent alterations of STEP phosphorylation and proteolysis in neurons. J Neurotrauma 29, 1982–1998 (2012). (PDF)

Von Reyn CR, Mott RE, Siman R, Smith DH, Meaney DF. Mechanisms of calpain mediated proteolysis of voltage gated sodium channel α-subunits following in vitro dynamic stretch injury. J Neurochem 121, 793–805 (2012). (PDF)

Spaethling J, Le L, Meaney DF. NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury. Neurobiol Dis 46, 646–654 (2012). (PDF)

Effgen GB, Hue CD, Vogel E 3rd, Panzer MB, Meaney DF, Bass CR, Morrison B 3rd. A Multiscale Approach to blast neurotrauma modeling: Part II - Methodology for inducing blast injury to in vitro models. Front Neurol 3, 23 (2012). (PDF)

Choo AM, Geddes-Klein DM, Hockenberry A, Scarsella D, Mesfin MN, Singh P, Patel TP, Meaney DF. NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult. Neurochem Int 60, 506–516 (2012). (PDF)

Ma M, Li L, Wang X, Bull DL, Shofer FS, Meaney DF, Neumar RW. Short-duration treatment with the calpain inhibitor MDL-28170 does not protect axonal transport in an in vivo model of traumatic axonal injury. J Neurotrauma 29, 445–451 (2012). (PDF)

Patel TP, Ventre SC, Meaney DF. Dynamic changes in neural circuit topology following mild mechanical injury in vitro. Ann Biomed Eng 40, 23–36 (2012). (PDF)

Ji J, Tyurina YY, Tang M, Feng W, Stolz DB, Clark RS, Meaney DF, Kochanek PM, Kagan VE, Bayır H. Mitochondrial injury after mechanical stretch of cortical neurons in vitro: Biomarkers of apoptosis and selective peroxidation of anionic phospholipids. J Neurotrauma 29, 776–788 (2012). (PDF)


Singh P, Doshi S, Spaethling JM, Hockenberry AJ, Patel TP, Geddes-Klein DM, Lynch DR, Meaney DF. N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit. J Biol Chem 287(6), 4348-59 (2011). (PDF)

LaPlaca MC, Meaney DF. Perspectives on the role of bioengineering in neurotrauma research. J Neurotrauma 28, 2201–2202 (2011). (PDF)

Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72, 57–71 (2011). (PDF)

Browne KD, Chen XH, Meaney DF, Smith DH. Mild traumatic brain injury and diffuse axonal injury in swine. J Neurotrauma 28, 1747–1755 (2011). (PDF)

Singh P, Hockenberry AJ, Tiruvadi VR, Meaney DF. Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission. PLoS Comput Biol 7, (2011). (PDF)

Meaney DF, Smith DH. Biomechanics of concussion. Clin Sports Med 30, 19–31 (2011). (PDF)

Von Reyn CR, Spaethling JM, Mesfin MN, Ma M, Neumar RW, Smith DH, Siman R, Meaney DF. Calpain mediates proteolysis of the voltage-gated sodium channel subunit. J Neurosci 29, 10350–10356 (2009). (PDF)


Chen YC, Smith DH, Meaney DF. In-vitro approaches for studying blast-induced traumatic brain injury. J Neurotrauma 26, 861–876 (2009). (PDF)

Miller WJ, Leventhal I, Scarsella D, Haydon PG, Janmey P, Meaney DF. Mechanically induced reactive gliosis causes ATP-mediated alterations in astrocyte stiffness. J Neurotrauma 26, 789–797 (2009). (PDF)

Ma M, Matthews BT, Lampe JW, Meaney DF, Shofer FS, Neumar RW. Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury. Exp Neurol 215, 119–127 (2009). (PDF)


Spaethling JM, Klein DM, Singh P, Meaney DF. Calcium-permeable AMPA receptors appear in cortical neurons after traumatic mechanical injury and contribute to neuronal fate. J Neurotrauma 25, 1207–1216 (2008). (PDF)

Zhang J, Groff RF 4th, Chen XH, Browne KD, Huang J, Schwartz ED, Meaney DF, Johnson VE, Stein SC, Rojkjaer R, Smith DH. Hemostatic and neuroprotective effects of human recombinant activated factor VII therapy after traumatic brain injury in pigs. Exp Neurol 210, 645–655 (2008). (PDF)

Bell TJ, Miyashiro KY, Sul JY, McCullough R, Buckley PT, Jochems J, Meaney DF, Haydon P, Cantor C, Parsons TD, Eberwine J. Cytoplasmic BKCa channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons. Proc Natl Acad Sci 105, 1901–1906 (2008). (PDF)


Ding S, Fellin T, Zhu Y, Lee SY, Auberson YP, Meaney DF, Coulter DA, Carmignoto G, Haydon PG. Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus. J Neurosci 27, 10674–10684 (2007). (PDF)

Spaethling JM, Geddes-Klein DM, Miller WJ, von Reyn CR, Singh P, Mesfin M, Bernstein SJ, Meaney DF. Linking impact to cellular and molecular sequelae of CNS injury: Modeling in vivo complexity with in vitro simplicity. Prog Brain Res 161, 27–39 (2007). (PDF)

D'Ascenzo M, Fellin T, Terunuma M, Revilla-Sanchez R, Meaney DF, Auberson YP, Moss SJ, Haydon PG. mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc Natl Acad Sci 104, 1995–2000 (2007). (PDF)


Geddes-Klein DM, Serbest G, Mesfin MN, Cohen AS, Meaney DF. Pharmacologically induced calcium oscillations protect neurons from increases in cytosolic calcium after trauma. J Neurochem 97, 462–474 (2006). (PDF)

Geddes-Klein DM, Schiffman KB, Meaney DF. Mechanisms and consequences of neuronal stretch injury in vitro differ with the model of trauma. J Neurotrauma 23, (2006). (PDF)

Georges PC, Miller WJ, Meaney DF, Sawyer ES, Janmey PA. Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. Biophys J 90, 3012–3018 (2006). (PDF)

DeRidder MN, Simon MJ, Siman R, Auberson YP, Raghupathi R, Meaney DF. Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition. Neurobiol Dis 22, 165–176 (2006). (PDF)

Pfister BJ, Iwata A, Taylor AG, Wolf JA, Meaney DF, Smith DH. Development of transplantable nervous tissue constructs comprised of stretch-grown axons. J Neurosci Methods 153, 95–103 (2006). (PDF)


Longhi L, Saatman KE, Fujimoto S, Raghupathi R, Meaney DF, Davis J, McMillan B S A, Conte V, Laurer HL, Stein S, Stocchetti N, McIntosh TK. Temporal window of vulnerability to repetitive experimental concussive brain injury. Neurosurgery 56, 364-74; discussion 364-74 (2005). (PDF)


Ledoux WR, Meaney DF, Hillstrom HJ. A quasi-linear, viscoelastic, structural model of the plantar soft tissue with frequency-sensitive damping properties. J Biomech Eng 126, 831–7 (2004). (PDF)

Lusardi TA, Rangan J, Sun D, Smith DH, Meaney DF. A device to study the initiation and propagation of calcium transients in cultured neurons after mechanical stretch. Ann Biomed Eng 32, 1546–58 (2004). (PDF)

Pfister BJ, Iwata A, Meaney DF, Smith DH. Extreme stretch growth of integrated axons. J Neurosci 24, 7978–7983 (2004). (PDF)

Chen XH, Siman R, Iwata A, Meaney DF, Trojanowski JQ, Smith DH. Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma. Am J Pathol 165, 357–71 (2004). (PDF)

Davis JE, Eberwine JH, Hinkle DA, Marciano PG, Meaney DF, McIntosh TK. Methodological considerations regarding single-cell gene expression profiling for brain injury. Neurochem Res 29, 1113–21 (2004). (PDF)

Iwata A, Stys PK, Wolf JA, Chen XH, Taylor AG, Meaney DF, Smith DH. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. J Neurosci 24, 4605–4613 (2004). (PDF)

Lusardi TA, Wolf JA, Putt ME, Smith DH, Meaney DF. Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons. J Neurotrauma 21, 61–72 (2004). (PDF)


Smith DH, Meaney DF, Shull WH. Diffuse axonal injury in head trauma. J Head Trauma Rehabil 18, 307–16 (2003). (PDF)

Bain AC, Shreiber DI, Meaney DF. Modeling of microstructural kinematics during simple elongation of central nervous system tissue. J Biomech Eng 125, 798–804 (2003). (PDF)

Meaney DF. Relationship between structural modeling and hyperelastic material behavior: Application to CNS white matter. Biomech Model Mechanobiol 1, 279–293 (2003). (PDF)

Saatman KE, Abai B, Grosvenor A, Vorwerk CK, Smith DH, Meaney DF. Traumatic axonal injury results in biphasic calpain activation and retrograde tansport impairment in mice. J Cereb Blood Flow Metab 23, 34–42 (2003). (PDF)

Lusardi TA, Smith DH, Wolf JA, Meaney DF. The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons. Biorheology 40, 401–9 (2003). (PDF)


Marciano PG, Eberwine JH, Ragupathi R, Saatman KE, Meaney DF, McIntosh TK. Expression profiling following traumatic brain injury: A review. Neurochem Res 27, 1147–55 (2002). (PDF)

Smith DH, Meaney DF. Roller coasters, g forces, and brain trauma: On the wrong track? J Neurotrauma 19, 1117–1120 (2002). (PDF)


Meaney DF, Margulies SS, Smith DH. Diffuse axonal injury. J Neurosurg 95, 1108–10 (2001). (PDF)

Bain AC, Raghupathi R, Meaney DF. Dynamic stretch correlates to both morphological abnormalities and electrophysiological impairment in a model of traumatic axonal injury. J Neurotrauma 18, 499-511 (2001). (PDF)

Smith DH, Wolf JA, Meaney DF. A new strategy to produce sustained growth of central nervous system axons: Continuous mechanical tension. Tissue Eng 7, 131–139 (2001). (PDF)

2000 and Prior

Prange MT, Meaney DF, Margulies SS. Defining brain mechanical properties: Effects of region, direction, and species. Stapp Car Crash J 44, 205–13 (2000). (PDF)

Bain AC, Meaney DF. Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injury. J Biomech Eng 122, 615 (2000). (PDF)

Pollack SR, Meaney DF, Levine EM, Litt M, Johnston ED. Numerical model and experimental validation of microcarrier motion in a rotating bioreactor. Tissue Eng 6, 519–530 (2000). (PDF)

Smith FM, Raghupathi R, MacKinnon MA, McIntosh TK, Saatman KE, Meaney DF, Graham DI. TUNEL-positive staining of surface contusions after fatal head injury in man. Acta Neuropathol 100, 537–45 (2000). (PDF)
Smith DH, Nonaka M, Miller R, Leoni M, Chen XH, Alsop D, Meaney DF. Immediate coma following inertial brain injury dependent on axonal damage in the brainstem. J Neurosurg 93, 315–322 (2000). (PDF)

Morrison B 3rd, Meaney DF, Margulies SS, McIntosh TK. Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: Relationship to mechanical parameters. J Biomech Eng 122, 224–30 (2000). (PDF)

Morrison B 3rd, Eberwine JH, Meaney DF, McIntosh TK. Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization. Neuroscience 96, 131–139 (2000). (PDF)

Smith DH, Chen XH, Nonaka M, Trojanowski JQ, Lee VM, Saatman KE, Leoni MJ, Xu BN, Wolf JA, Meaney DF. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J Neuropathol Exp Neurol 58, 982–92 (1999). (PDF)

Chen XH, Meaney DF, Xu BN, Nonaka M, McIntosh TK, Wolf JA, Saatman KE, Smith DH. Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig. J Neuropathol Exp Neurol 58, 588–96 (1999). (PDF)

Smith DH, Wolf JA, Lusardi TA, Lee VM, Meaney DF. High tolerance and delayed elastic response of cultured axons to dynamic stretch injury. J Neurosci 19, 4263–9 (1999). (PDF)

McGowan JC, McCormack TM, Grossman RI, Mendonça R, Chen XH, Berlin JA, Meaney DF, Xu BN, Cecil KM, McIntosh TK, Smith DH. Diffuse axonal pathology detected with magnetization transfer imaging following brain injury in the pig. Magn Reson Med 41, 727–33 (1999). (PDF)

Shreiber DI, Bain AC, Ross DT, Smith DH, Gennarelli TA, McIntosh TK, Meaney DF. Experimental investigation of cerebral contusion: histopathological and immunohistochemical evaluation of dynamic cortical deformation. J Neuropathol Exp Neurol 58, 153–64 (1999). (PDF)

Shreiber DI, Smith DH, Meaney DF. Immediate in vivo response of the cortex and the blood–brain barrier following dynamic cortical deformation in the rat. Neurosci Lett 259, 5–8 (1999). (PDF)

Morrison B 3rd, Saatman KE, Meaney DF, McIntosh TK. In vitro central nervous system models of mechanically induced trauma: A review. J Neurotrauma 15 (11): 911-28 (1998). (PDF)

Smith DH, Cecil KM, Meaney DF, Chen XH, McIntosh TK, Gennarelli TA, Lenkinski RE. Magnetic resonance spectroscopy of diffuse brain trauma in the pig. J Neurotrauma 15, 665–674 (1998). (PDF)

Cecil KM, Lenkinski RE, Meaney DF, McIntosh TK, Smith DH. High-field proton magnetic resonance spectroscopy of a swine model for axonal injury. J Neurochem 70, 2038–44 (1998). (PDF)

Morrison B 3rd, Meaney DF, McIntosh TK. Mechanical characterization of an in vitro device designed to quantitatively injure living brain tissue. Ann Biomed Eng 26, 381–90 (1998). (PDF)

Smith DH, Chen XH, Xu BN, McIntosh TK, Gennarelli TA, Meaney DF. Characterization of diffuse axonal pathology and selective hippocampal damage following inertial brain trauma in the pig. J Neuropathol Exp Neurol 56, 822–34 (1997). (PDF)

Kimura H, Meaney DF, McGowan JC, Grossman RI, Lenkinski RE, Ross DT, McIntosh TK, Gennarelli TA, Smith DH. Magnetization transfer imaging of diffuse axonal injury following experimental brain injury in the pig: characterization by magnetization transfer ratio with histopathologic correlation. J Comput Assist Tomogr 20, 540–6 (1996). (PDF)

McIntosh TK, Smith DH, Meaney DF, Kotapka MJ, Gennarelli TA, Graham DI. Neuropathological sequelae of traumatic brain injury: Relationship to neurochemical and biomechanical mechanisms. Lab Invest 74, 315–42 (1996). (PDF)

Landsman AS, Meaney DF, Cargill RS 2nd, Macarak EJ, Thibault LE. 1995 William J. Stickel Gold Award. High strain rate tissue deformation: A theory on the mechanical etiology of diabetic foot ulcerations. J Am Podiatr Med Assoc 85, 519–527 (1995). (PDF)

Meaney DF, Smith DH, Shreiber DI, Bain AC, Miller RT, Ross DT, Gennarelli TA. Biomechanical analysis of experimental diffuse axonal injury. J Neurotrauma 12, 689-94 (1995). (PDF)

Smith DH, Meaney DF, Lenkinski RE, Alsop DC, Grossman R, Kimura H, McIntosh TK, Gennarelli TA. New magnetic resonance imaging techniques for the evaluation of traumatic brain injury. J Neurotrauma 12, 573–577 (1995). (PDF)

Meaney, DF. Mechanical properties of implantable biomaterials. Clin Podiatr Med Surg 12, 363–84 (1995). (PDF)

Smith DH, Soares HD, Pierce JS, Perlman KG, Saatman KE, Meaney DF, Dixon CE, McIntosh TK. A model of parasagittal controlled cortical impact in the mouse: Cognitive and histopathologic effects. J Neurotrauma 12, 169–178 (1995). (PDF)

Meaney DF, Ross DT, Winkelstein BA, Brasko J, Goldstein D, Bilston LB, Thibault LE, Gennarelli TA. Modification of the cortical impact model to produce axonal injury in the rat cerebral cortex. J Neurotrauma 11, 599–612 (1994). (PDF)

Ross DT, Meaney DF, Sabol MK, Smith DH, Gennarelli TA. Distribution of forebrain diffuse axonal injury following inertial closed head injury in miniature swine. Exp Neurol 126, 291–298 (1994). (PDF)

Thibault LE, Meaney DF, Anderson BJ, Marmarou A. Biomechanical aspects of a fluid percussion model of brain injury. J Neurotrauma 9, 311–322 (1992). (PDF)